WormBase Tree Display for Gene: WBGene00006537
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WBGene00006537 | SMap | S_parent | Sequence | C36E8 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | tbb-2 | |||||||
Sequence_name | C36E8.5 | ||||||||
Molecular_name | C36E8.5 | ||||||||
C36E8.5.1 | |||||||||
CE00913 | |||||||||
Other_name | TUBB8 | ||||||||
rot-2 | CGC_data_submission | ||||||||
CELE_C36E8.5 | Accession_evidence | NDB | BX284603 | ||||||
Public_name | tbb-2 | ||||||||
DB_info | Database (10) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | tbb | ||||||||
Allele (24) | |||||||||
Legacy_information | [C.elegansII] NMK. Encodes beta tubulin. [NW] | ||||||||
[Schnabel H] maternal-effect embryonic lethal with defect in rotation of centrosome pair and associated pronuclei before first cleavage | |||||||||
Strain (21) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (21) | |||||||||
Ortholog (70) | |||||||||
Paralog (16) | |||||||||
Structured_description | Concise_description | tbb-2 encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-2 is redundant for embryonic viability, due to its paralog TBB-1; however, unlike its paralog TBB-1 it is preferred for normal microtubule severing by the katanin complex MEI-1/MEI-2; TBB-2 is required together with TBB-1, TBA-1, and tba-2 to make spindle structures in embryos and TBB-2 also affects the stability of the PO spindle; first divisions are normal in null mutants, but putative gain-of-function mutations affect centrosome rotations in the P0, P1, and EMS blastomeres of the early embryo, and affect pronuclear migration and meiosis. | Paper_evidence (11) | ||||||
Person_evidence | WBPerson399 | ||||||||
Curator_confirmed | WBPerson48 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in meiotic spindle organization. Located in spindle microtubule. Expressed in several structures, including germ line; gonad; oocyte; tail; and touch receptor neurons. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 1 and congenital fibrosis of the extraocular muscles 3A. Is an ortholog of several human genes including TUBB3 (tubulin beta 3 class III); TUBB6 (tubulin beta 6 class V); and TUBB8B (tubulin beta 8B). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0090137 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20772) | ||||
DOID:0081017 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20772) | ||||||
EFO:MONDO:0014769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20773) | ||||||
Molecular_info | Corresponding_CDS | C36E8.5 | |||||||
Corresponding_transcript | C36E8.5.1 | ||||||||
Other_sequence (265) | |||||||||
Associated_feature (13) | |||||||||
Experimental_info | RNAi_result (50) | ||||||||
Expr_pattern (12) | |||||||||
Drives_construct | WBCnstr00002578 | ||||||||
WBCnstr00034316 | |||||||||
WBCnstr00039276 | |||||||||
Construct_product (15) | |||||||||
Antibody | WBAntibody00000703 | ||||||||
WBAntibody00000712 | |||||||||
WBAntibody00002338 | |||||||||
Microarray_results (26) | |||||||||
Expression_cluster (206) | |||||||||
Interaction (328) | |||||||||
Map_info (3) | |||||||||
Reference (92) | |||||||||
Remark | Sequence connection updated based on email from Chenggang Lu | ||||||||
cgc3909 linked tbb-2 to B0272.1, which is not approved by CGC | CGC_data_submission | ||||||||
Method | Gene |