WormBase Tree Display for Gene: WBGene00005157
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WBGene00005157 | Identity (5) | |||||
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Gene_info | Gene_class | srf | ||||
Allele | WBVar00142871 | Inferred_automatically | From strain object: CL264 | |||
Legacy_information | [C.elegansII] dv38 : altered cuticle labelling, ectopic WGA lectin binding, pleiotropic defects: Unc, Egl, Mab, Mig(DTC), variable neuronal abnormalities,SDS-sensitive dauers; enhance lin-12(gf),[Link et al. 1992; CL] | |||||
Strain | WBStrain00005059 | |||||
Structured_description | Concise_description | srf-8 was identified as a mutation that alters the surface antigenicity of the cuticle in C. elegans; srf-8 mutations show altered binding to antibodies raised against the cuticles of wild-type worms, and lectins like wheat germ agglutinin; srf-8 mutants also show uncoordinated movement, abnormal gonadal and male tail morphologies, and male infertility. | Paper_evidence | WBPaper00001576 | ||
WBPaper00001706 | ||||||
Curator_confirmed | WBPerson324 | |||||
Date_last_updated | 10 Oct 2011 00:00:00 | |||||
Disease_info | Experimental_model | DOID:104 | Homo sapiens | Paper_evidence | WBPaper00031925 | |
Curator_confirmed | WBPerson324 | |||||
Date_last_updated | 07 Nov 2023 00:00:00 | |||||
Disease_relevance | C. elegans is used as a model system to study bacterial adherence via biofilm formation and to identify genes in the infectious agent as well as the host that are required for infection; elegans srf genes are required for cuticle surface properties like binding to antigens, and for the adherence of bacterial pathogens like Yersinia pseduotuberculosis and Yersinia pestis via biofilms. | Homo sapiens | Paper_evidence | WBPaper00001706 | ||
WBPaper00026735 | ||||||
WBPaper00029153 | ||||||
Curator_confirmed | WBPerson324 | |||||
Date_last_updated | 06 Mar 2013 00:00:00 | |||||
Models_disease_in_annotation | WBDOannot00000019 | |||||
Experimental_info | Interaction | WBInteraction000052126 | ||||
Map_info (2) | ||||||
Reference (12) | ||||||
Method | Gene |