WormBase Tree Display for Gene: WBGene00005009
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| WBGene00005009 | Evidence | Paper_evidence | WBPaper00005903 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C09H6 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | spr-4 | Person_evidence | WBPerson220 | |||||
| Sequence_name | C09H6.1 | ||||||||
| Molecular_name | C09H6.1a | ||||||||
| C09H6.1a.1 | |||||||||
| CE30487 | |||||||||
| C09H6.1b | |||||||||
| CE15609 | |||||||||
| C09H6.1b.1 | |||||||||
| Other_name | CELE_C09H6.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | spr-4 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info (12) | |||||||||
| Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00060103 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Sep 2020 00:00:00 | ||||||||
| DOID:10652 | Homo sapiens | Paper_evidence | WBPaper00045043 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 21 Oct 2014 00:00:00 | ||||||||
| Disease_relevance | Human RE1-silencing transcription factor (REST), also known as Neuron-restrictive silencer factor (NRSF) is a transcriptional repressor, also involved in repression of neuronal genes during embryonic development that is down-regulated after terminal neuronal differentiation; recent transcriptional profiling data indicate that REST is induced in the aging brain and declines in Alzhemier''s disease (AD); REST is neuroprotective, repressing genes involved in cell death and strongly inhibiting tau phosphorylation, associated with AD; REST-deficient mice showed a progressive age-related neurodegenerative phenotype; in C. elegans, mutations in the multi-zinc finger transcripton factors, spr-3 and spr-4, structurally resembling mammalian REST, and a mutation in spr-1, orthologous to CoREST, showed significantly reduced survival relative to wild-type controls, with spr-4(by105) most affected; further, transgenic expression of human REST could functionally replace wild-type spr-4, as indicated by reducing paraquat-induced elevated ROS levels in spr-4(by105) and by repressing the presenilin gene hop-1, which is repressed by SPR-4; SPR-4 also modulated the neurotoxicity of A-beta in an C. elegans line that expresses A-beta42 in glutamatergic neurons and undergoes age-dependent neuronal loss, when this line was crossed with the spr-4(by105) mutant, the resulting line expressed A-beta42 and showed significantly accelerated neurodegeneration; thus, SPR-4 protects against both oxidative stress and A-beta toxicity, consistent with a general role in stress resistance. | Homo sapiens | Paper_evidence | WBPaper00045043 | |||||
| Accession_evidence | OMIM | 600571 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 22 Oct 2014 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000324 | ||||||||
| WBDOannot00000803 | |||||||||
| Molecular_info | Corresponding_CDS | C09H6.1a | |||||||
| C09H6.1b | |||||||||
| Corresponding_CDS_history | C09H6.1:wp77 | ||||||||
| Corresponding_transcript | C09H6.1a.1 | ||||||||
| C09H6.1b.1 | |||||||||
| Other_sequence | CJC02768_1 | ||||||||
| CSC01877_1 | |||||||||
| FD514142.1 | |||||||||
| CBC09654_1 | |||||||||
| Tcol_isotig15605 | |||||||||
| Associated_feature | WBsf656606 | ||||||||
| WBsf656607 | |||||||||
| WBsf984342 | |||||||||
| WBsf984343 | |||||||||
| WBsf1010187 | |||||||||
| WBsf218120 | |||||||||
| WBsf218121 | |||||||||
| Transcription_factor | WBTranscriptionFactor000745 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00002924 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00114340 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00028761 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00114539 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00040270 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00091422 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00114538 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr11697 | ||||||||
| Expr1023301 | |||||||||
| Expr1032493 | |||||||||
| Expr1144339 | |||||||||
| Expr2016091 | |||||||||
| Expr2034326 | |||||||||
| Drives_construct | WBCnstr00019317 | ||||||||
| WBCnstr00035270 | |||||||||
| Construct_product | WBCnstr00017355 | ||||||||
| WBCnstr00019317 | |||||||||
| WBCnstr00035270 | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (109) | |||||||||
| Interaction (58) | |||||||||
| Map_info | Map | I | Position | 2.52686 | Error | 0.014877 | |||
| Positive | Positive_clone | C09H6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4693 | |||||||
| Pseudo_map_position | |||||||||
| Reference (22) | |||||||||
| Remark | published in Wen et al., PNAS 97: 14527-14529, 2000 | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
