WormBase Tree Display for Gene: WBGene00004988
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| WBGene00004988 | SMap | S_parent | Sequence | T08A9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | spp-3 | |||||||
| Sequence_name | T08A9.7 | ||||||||
| Molecular_name | T08A9.7 | ||||||||
| T08A9.7.1 | |||||||||
| CE31233 | |||||||||
| Other_name | CELE_T08A9.7 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | spp-3 | ||||||||
| DB_info | Database | AceView | gene | XH934 | |||||
| WormQTL | gene | WBGene00004988 | |||||||
| WormFlux | gene | WBGene00004988 | |||||||
| NDB | locus_tag | CELE_T08A9.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004988|UniProtKB=Q22336 | |||||||
| family | PTHR21579 | ||||||||
| NCBI | gene | 180993 | |||||||
| RefSeq | protein | NM_076834.8 | |||||||
| TREEFAM | TREEFAM_ID | TF343148 | |||||||
| TrEMBL | UniProtAcc | Q22336 | |||||||
| UniProt_GCRP | UniProtAcc | Q22336 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | spp | ||||||||
| Allele (14) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00074946 | ||||||||
| 00074947 | |||||||||
| 00074948 | |||||||||
| 00074949 | |||||||||
| 00074950 | |||||||||
| Ortholog (25) | |||||||||
| Paralog (12) | |||||||||
| Structured_description | Concise_description | spp-3 encodes an antimicrobial peptide that belongs to the SPP-protein family, called caenopores, with structural similarity to saposin-like proteins (SAPLIPs), the amoebapores and the mammalian NK-lysin and granulysin; caenopores are part of the worm's innate immune system and interact with and eliminate bacteria via membrane pore-forming activity; C. elegans has at least 33 putative SPP proteins; in an heterologous expression system, spp-3 formed pores in liposomes, and showed antimicrobial activity against several gram- negative and positive bacteria such as E. coli, P. aeruginosa, Ph. luminescence, X. nematophila, Y. enterocolitica, B. megaterium and B. thuringiensis; spp-3 is expressed in the intestine and the SDQR head neuron. | Paper_evidence | WBPaper00041167 | |||||
| WBPaper00035289 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 17 Sep 2013 00:00:00 | ||||||||
| Automated_description | Enables identical protein binding activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Located in protein-containing complex. Expressed in SDQR. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T08A9.7 | |||||||
| Corresponding_transcript | T08A9.7.1 | ||||||||
| Other_sequence | CRC07887_1 | ||||||||
| CBC05377_1 | |||||||||
| CR08323 | |||||||||
| CJC04748_1 | |||||||||
| Associated_feature | WBsf899530 | Paper_evidence | WBPaper00041167 | ||||||
| WBsf899531 | Paper_evidence | WBPaper00041167 | |||||||
| WBsf899532 | Paper_evidence | WBPaper00041167 | |||||||
| WBsf899533 | Paper_evidence | WBPaper00041167 | |||||||
| WBsf1005803 | |||||||||
| WBsf1005804 | |||||||||
| WBsf1005805 | |||||||||
| WBsf1023225 | |||||||||
| WBsf237567 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00082192 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00052828 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092241 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00082199 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr10056 | ||||||||
| Expr1028065 | |||||||||
| Expr1156430 | |||||||||
| Expr2016081 | |||||||||
| Expr2034317 | |||||||||
| Drives_construct (2) | |||||||||
| Construct_product | WBCnstr00015028 | ||||||||
| WBCnstr00035289 | |||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (211) | |||||||||
| Interaction (257) | |||||||||
| Map_info | Map | X | Position | -1.7753 | |||||
| Positive | Positive_clone | T08A9 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (9) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
