WormBase Tree Display for Gene: WBGene00004988
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WBGene00004988 | SMap | S_parent | Sequence | T08A9 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | spp-3 | |||||||
Sequence_name | T08A9.7 | ||||||||
Molecular_name | T08A9.7 | ||||||||
T08A9.7.1 | |||||||||
CE31233 | |||||||||
Other_name | CELE_T08A9.7 | Accession_evidence | NDB | BX284606 | |||||
Public_name | spp-3 | ||||||||
DB_info | Database | AceView | gene | XH934 | |||||
WormQTL | gene | WBGene00004988 | |||||||
WormFlux | gene | WBGene00004988 | |||||||
NDB | locus_tag | CELE_T08A9.7 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00004988|UniProtKB=Q22336 | |||||||
family | PTHR21579 | ||||||||
NCBI | gene | 180993 | |||||||
RefSeq | protein | NM_076834.8 | |||||||
TREEFAM | TREEFAM_ID | TF343148 | |||||||
TrEMBL | UniProtAcc | Q22336 | |||||||
UniProt_GCRP | UniProtAcc | Q22336 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | spp | ||||||||
Allele (14) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (5) | |||||||||
Ortholog (26) | |||||||||
Paralog (12) | |||||||||
Structured_description | Concise_description | spp-3 encodes an antimicrobial peptide that belongs to the SPP-protein family, called caenopores, with structural similarity to saposin-like proteins (SAPLIPs), the amoebapores and the mammalian NK-lysin and granulysin; caenopores are part of the worm's innate immune system and interact with and eliminate bacteria via membrane pore-forming activity; C. elegans has at least 33 putative SPP proteins; in an heterologous expression system, spp-3 formed pores in liposomes, and showed antimicrobial activity against several gram- negative and positive bacteria such as E. coli, P. aeruginosa, Ph. luminescence, X. nematophila, Y. enterocolitica, B. megaterium and B. thuringiensis; spp-3 is expressed in the intestine and the SDQR head neuron. | Paper_evidence | WBPaper00041167 | |||||
WBPaper00035289 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 17 Sep 2013 00:00:00 | ||||||||
Automated_description | Enables identical protein binding activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Located in protein-containing complex. Expressed in SDQR. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | T08A9.7 | |||||||
Corresponding_transcript | T08A9.7.1 | ||||||||
Other_sequence | CRC07887_1 | ||||||||
CBC05377_1 | |||||||||
CR08323 | |||||||||
CJC04748_1 | |||||||||
Associated_feature (9) | |||||||||
Experimental_info | RNAi_result | WBRNAi00082192 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00052828 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00092241 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00082199 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (5) | |||||||||
Drives_construct | WBCnstr00015028 | ||||||||
WBCnstr00035289 | |||||||||
Construct_product | WBCnstr00015028 | ||||||||
WBCnstr00035289 | |||||||||
Microarray_results (17) | |||||||||
Expression_cluster (213) | |||||||||
Interaction (257) | |||||||||
Map_info | Map | X | Position | -1.7753 | |||||
Positive | Positive_clone | T08A9 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Pseudo_map_position | |||||||||
Reference | WBPaper00003435 | ||||||||
WBPaper00006437 | |||||||||
WBPaper00024209 | |||||||||
WBPaper00027295 | |||||||||
WBPaper00028482 | |||||||||
WBPaper00035289 | |||||||||
WBPaper00041167 | |||||||||
WBPaper00064841 | |||||||||
WBPaper00065877 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |