WormBase Tree Display for Gene: WBGene00004985
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WBGene00004985 | SMap | S_parent | Sequence | T05E11 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | spo | ||||||
Allele (16) | |||||||
Legacy_information | [Dernburg AF] ok79 is 1227 bp deletion, presumed null. Homozygotes morphologically normal, Mel (>99%), Him, defective segregation of all chromosomes, meiotic exchange <1% of wildtype, normal synapsis of homologues. Encodes homologue of budding yeast Spo11p. | ||||||
Strain | WBStrain00034685 | ||||||
WBStrain00035158 | |||||||
WBStrain00035163 | |||||||
WBStrain00035164 | |||||||
WBStrain00000277 | |||||||
WBStrain00000282 | |||||||
WBStrain00007860 | |||||||
WBStrain00047223 | |||||||
WBStrain00047221 | |||||||
WBStrain00047220 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (23) | |||||||
Ortholog (36) | |||||||
Structured_description | Concise_description | spo-11 encodes an ortholog of Spo11p in S. cerevisiae that is required for meiotic DNA recombination, and (in conjunction with CHK-2 and MRE-11) for the localization of RAD-51 to foci in late zygotene/early pachytene nuclei; like its yeast ortholog, SPO-11 is related to a subunit of archaebacterial topoisomerase VI, and probably causes double-stranded DNA breaks through a topoisomerase-like transesterase mechanism; however, unlike Spo11p, SPO-11 is dispensable for homologous synapsis and formation of the synaptonemal complex; SPO-11 is active even in syp-1 mutants where its double-stranded breaks cannot be correctly processed; spo-11 is transcribed in the germline. | Paper_evidence | WBPaper00003166 | |||
WBPaper00005462 | |||||||
WBPaper00006010 | |||||||
WBPaper00012991 | |||||||
WBPaper00013229 | |||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Predicted to enable DNA binding activity. Involved in meiotic DNA double-strand break processing. Predicted to be located in nuclear chromosome. Is an ortholog of human SPO11 (SPO11 initiator of meiotic double strand breaks). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | T05E11.4a | |||||
T05E11.4b | |||||||
Corresponding_transcript | T05E11.4a.1 | ||||||
T05E11.4b.1 | |||||||
Other_sequence | FD514501.1 | ||||||
JI175391.1 | |||||||
Dviv_isotig17985 | |||||||
CSC00934_1 | |||||||
Dviv_isotig17984 | |||||||
Associated_feature | WBsf652193 | ||||||
WBsf997770 | |||||||
WBsf1018175 | |||||||
WBsf230830 | |||||||
Experimental_info | RNAi_result (23) | ||||||
Expr_pattern | Expr1027139 | ||||||
Expr1032481 | |||||||
Expr1156137 | |||||||
Expr2016063 | |||||||
Expr2034299 | |||||||
Drives_construct | WBCnstr00035292 | ||||||
Construct_product | WBCnstr00035292 | ||||||
Microarray_results (19) | |||||||
Expression_cluster (117) | |||||||
Interaction (295) | |||||||
Map_info | Map | IV | Position | 4.89498 | Error | 0.004494 | |
Well_ordered | |||||||
Positive | Positive_clone | T05E11 | Person_evidence | WBPerson136 | |||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
Mapping_data | Multi_point | 4609 | |||||
Reference (133) | |||||||
Remark | Data extracted from Dernburg et al. (1998) | ||||||
Method | Gene |