WormBase Tree Display for Gene: WBGene00004985
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WBGene00004985 | SMap | S_parent | Sequence | T05E11 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | spo-11 | Person_evidence | WBPerson1547 | |||||
Sequence_name | T05E11.4 | ||||||||
Molecular_name | T05E11.4a | ||||||||
T05E11.4a.1 | |||||||||
CE06363 | |||||||||
T05E11.4b | |||||||||
CE49824 | |||||||||
T05E11.4b.1 | |||||||||
Other_name | CELE_T05E11.4 | Accession_evidence | NDB | BX284604 | |||||
Public_name | spo-11 | ||||||||
DB_info | Database (12) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | spo | ||||||||
Allele (16) | |||||||||
Legacy_information | [Dernburg AF] ok79 is 1227 bp deletion, presumed null. Homozygotes morphologically normal, Mel (>99%), Him, defective segregation of all chromosomes, meiotic exchange <1% of wildtype, normal synapsis of homologues. Encodes homologue of budding yeast Spo11p. | ||||||||
Strain | WBStrain00034685 | ||||||||
WBStrain00035158 | |||||||||
WBStrain00035163 | |||||||||
WBStrain00035164 | |||||||||
WBStrain00000277 | |||||||||
WBStrain00000282 | |||||||||
WBStrain00007860 | |||||||||
WBStrain00047223 | |||||||||
WBStrain00047221 | |||||||||
WBStrain00047220 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (23) | |||||||||
Ortholog (36) | |||||||||
Structured_description | Concise_description | spo-11 encodes an ortholog of Spo11p in S. cerevisiae that is required for meiotic DNA recombination, and (in conjunction with CHK-2 and MRE-11) for the localization of RAD-51 to foci in late zygotene/early pachytene nuclei; like its yeast ortholog, SPO-11 is related to a subunit of archaebacterial topoisomerase VI, and probably causes double-stranded DNA breaks through a topoisomerase-like transesterase mechanism; however, unlike Spo11p, SPO-11 is dispensable for homologous synapsis and formation of the synaptonemal complex; SPO-11 is active even in syp-1 mutants where its double-stranded breaks cannot be correctly processed; spo-11 is transcribed in the germline. | Paper_evidence | WBPaper00003166 | |||||
WBPaper00005462 | |||||||||
WBPaper00006010 | |||||||||
WBPaper00012991 | |||||||||
WBPaper00013229 | |||||||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Predicted to enable DNA binding activity. Involved in meiotic DNA double-strand break processing. Predicted to be located in nuclear chromosome. Is an ortholog of human SPO11 (SPO11 initiator of meiotic double strand breaks). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS (2) | ||||||||
Corresponding_transcript | T05E11.4a.1 | ||||||||
T05E11.4b.1 | |||||||||
Other_sequence | FD514501.1 | ||||||||
JI175391.1 | |||||||||
Dviv_isotig17985 | |||||||||
CSC00934_1 | |||||||||
Dviv_isotig17984 | |||||||||
Associated_feature (4) | |||||||||
Experimental_info | RNAi_result (23) | ||||||||
Expr_pattern | Expr1027139 | ||||||||
Expr1032481 | |||||||||
Expr1156137 | |||||||||
Expr2016063 | |||||||||
Expr2034299 | |||||||||
Drives_construct | WBCnstr00035292 | ||||||||
Construct_product | WBCnstr00035292 | ||||||||
Microarray_results (19) | |||||||||
Expression_cluster (117) | |||||||||
Interaction (295) | |||||||||
Map_info | Map | IV | Position | 4.89498 | Error | 0.004494 | |||
Well_ordered | |||||||||
Positive | Positive_clone | T05E11 | Person_evidence | WBPerson136 | |||||
Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
Mapping_data | Multi_point | 4609 | |||||||
Reference (133) | |||||||||
Remark | Data extracted from Dernburg et al. (1998) | ||||||||
Method | Gene |