WormBase Tree Display for Gene: WBGene00004910
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WBGene00004910 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | T03F7 | ||||
Identity | Version | 2 | |||||
Name | CGC_name | snf-11 | Person_evidence | WBPerson508 | |||
Sequence_name | T03F7.1 | ||||||
Molecular_name | T03F7.1 | ||||||
T03F7.1.1 | |||||||
CE40659 | |||||||
Other_name | gat-1 | Paper_evidence | WBPaper00024600 | ||||
CELE_T03F7.1 | Accession_evidence | NDB | BX284605 | ||||
Public_name | snf-11 | ||||||
DB_info | Database | AceView | gene | 5L784 | |||
WormQTL | gene | WBGene00004910 | |||||
WormFlux | gene | WBGene00004910 | |||||
NDB | locus_tag | CELE_T03F7.1 | |||||
Panther | gene | CAEEL|WormBase=WBGene00004910|UniProtKB=G5EF43 | |||||
family | PTHR11616 | ||||||
NCBI | gene | 191770 | |||||
RefSeq | protein | NM_073472.8 | |||||
TrEMBL | UniProtAcc | G5EF43 | |||||
UniProt_GCRP | UniProtAcc | G5EF43 | |||||
OMIM | gene | 137165 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | snf | ||||||
Allele (59) | |||||||
Strain | WBStrain00033395 | ||||||
WBStrain00033396 | |||||||
WBStrain00033398 | |||||||
WBStrain00033399 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (11) | |||||||
Ortholog (40) | |||||||
Paralog (13) | |||||||
Structured_description | Concise_description | snf-11 encodes an electrogenic, Na[+]/Cl[-]-coupled, high-affinity GABA transporter that is required in vivo for GABA uptake, and for normal aldicarb sensitivity; SNF-11 is orthologous to human SLC6A1 (OMIM:137165); SNF-11 is selective for GABA with a Kt of ~15 microM, has an EC50 value of 168 microM, is blocked by GAT1 inhibitor SKF89976A, and has a 2:1:1 stoichiometry of Na[+]:Cl[-]:GABA; SNF-11 is expressed in several GABAergic neurons, in some other non-GABAergic neurons of the head and retrovesicular ganglion (e.g., RID), and in muscle cells; snf-11(ok156) null mutants fail to show GABA uptake in at least some GABAergic cells, and in cell culture; snf-11(ok156) mutants exhibit GABA-dependent aldicarb resistance, and show abnormal head foraging and defecation in a genetically sensitized background (GABA-transport dependent, with an unc-25 null allele); while unsensitized snf-11(ok156) mutants have grossly normal phenotype, cell cultures from snf-11(ok156) embryos completely lack normal GABA uptake. | Paper_evidence | WBPaper00024600 | |||
WBPaper00027352 | |||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 05 Jan 2008 00:00:00 | ||||||
Automated_description | Enables gamma-aminobutyric acid:sodium:chloride symporter activity. Involved in gamma-aminobutyric acid transport. Located in neuron projection and neuronal cell body. Expressed in several structures, including GLR; enteric muscle; head mesodermal cell; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in myoclonic-atonic epilepsy and temporal lobe epilepsy. Is an ortholog of human SLC6A1 (solute carrier family 6 member 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0060475 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11042) | ||
DOID:0050741 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11042) | ||||
DOID:3328 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11042) | ||||
Molecular_info | Corresponding_CDS | T03F7.1 | |||||
Corresponding_CDS_history | T03F7.1:wp169 | ||||||
Corresponding_transcript | T03F7.1.1 | ||||||
Other_sequence (29) | |||||||
Associated_feature | WBsf668679 | ||||||
WBsf669372 | |||||||
WBsf716831 | |||||||
WBsf1001313 | |||||||
WBsf234522 | |||||||
Experimental_info | RNAi_result | WBRNAi00052295 | Inferred_automatically | RNAi_primary | |||
Expr_pattern | Expr4376 | ||||||
Expr6581 | |||||||
Expr7836 | |||||||
Expr7837 | |||||||
Expr13160 | |||||||
Expr1018656 | |||||||
Expr1032440 | |||||||
Expr1155929 | |||||||
Expr2015944 | |||||||
Expr2034179 | |||||||
Drives_construct | WBCnstr00004041 | ||||||
WBCnstr00011950 | |||||||
WBCnstr00012949 | |||||||
WBCnstr00035328 | |||||||
Construct_product | WBCnstr00035328 | ||||||
Antibody | WBAntibody00001085 | ||||||
Microarray_results (18) | |||||||
Expression_cluster (195) | |||||||
Interaction (11) | |||||||
Map_info | Map | V | Position | 3.07267 | Error | 0.000861 | |
Positive | Positive_clone | T03F7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4230 | |||||
4365 | |||||||
Pseudo_map_position | |||||||
Reference (15) | |||||||
Remark | Sequence connection from [Rand JB] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |