WormBase Tree Display for Gene: WBGene00004321
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WBGene00004321 | SMap | S_parent | Sequence | F54E7 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | rcan-1 | Paper_evidence | WBPaper00048397 | |||
Person_evidence | WBPerson746 | ||||||
Sequence_name | F54E7.7 | ||||||
Molecular_name | F54E7.7 | ||||||
F54E7.7.1 | |||||||
CE31002 | |||||||
Other_name | DSCR1L | Accession_evidence | EMBL | AF176115 | |||
SC | Accession_evidence | EMBL | AF176115 | ||||
rcn-1 | Paper_evidence | WBPaper00005829 | |||||
Person_evidence | WBPerson746 | ||||||
CELE_F54E7.7 | Accession_evidence | NDB | BX284603 | ||||
Public_name | rcan-1 | ||||||
DB_info | Database (11) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | rcan | ||||||
Allele (25) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (18) | |||||||
Ortholog (43) | |||||||
Structured_description | Automated_description | Enables protein phosphatase 2B binding activity and protein serine/threonine phosphatase inhibitor activity. Involved in several processes, including male mating behavior; positive regulation of nematode male tail tip morphogenesis; and thermosensory behavior. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including non-striated muscle; pharyngeal cell; somatic nervous system; tail; and vulva. Used to study Down syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is an ortholog of human RCAN1 (regulator of calcineurin 1); RCAN2 (regulator of calcineurin 2); and RCAN3 (RCAN family member 3). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:14250 | Homo sapiens | Paper_evidence | WBPaper00005829 | ||
Accession_evidence | OMIM | 190685 | |||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 05 Jun 2017 00:00:00 | ||||||
Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:3040) | |||
Disease_relevance | DSCR1) gene is located in the Down Syndrome critical region (DSCR) of chromosome 21, and encodes an inhibitor of calcineurin-signalling pathways; in elegans, overexpression of rcan-1 could reproduce calcineurin loss-of-function phenotypes, providing in vivo proof of rcan-1 regulation of calcineurin; also, as with mbk-1, another DSCR gene ortholog in elegans, adjusting rcan-1 dosage could reverse the effects of its overexpression. | Homo sapiens | Paper_evidence | WBPaper00005829 | |||
Accession_evidence | OMIM | 190685 | |||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 05 Jun 2017 00:00:00 | ||||||
Models_disease_in_annotation | WBDOannot00000131 | ||||||
Molecular_info | Corresponding_CDS | F54E7.7 | |||||
Corresponding_transcript | F54E7.7.1 | ||||||
Other_sequence (28) | |||||||
Associated_feature | WBsf666918 | ||||||
WBsf992489 | |||||||
WBsf992490 | |||||||
WBsf992491 | |||||||
WBsf226716 | |||||||
Experimental_info | RNAi_result | WBRNAi00048353 | Inferred_automatically | RNAi_primary | |||
WBRNAi00015642 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00005533 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027915 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr2548 | ||||||
Expr11062 | |||||||
Expr13659 | |||||||
Expr1011498 | |||||||
Expr1032146 | |||||||
Expr1152149 | |||||||
Expr2015278 | |||||||
Expr2033512 | |||||||
Drives_construct | WBCnstr00008158 | ||||||
WBCnstr00010850 | |||||||
WBCnstr00037927 | |||||||
WBCnstr00039931 | |||||||
Construct_product | WBCnstr00008158 | ||||||
WBCnstr00037927 | |||||||
WBCnstr00039931 | |||||||
Antibody | WBAntibody00002649 | ||||||
Microarray_results (20) | |||||||
Expression_cluster (198) | |||||||
Interaction (169) | |||||||
Map_info | Map | III | Position | -1.45588 | Error | 0.000648 | |
Positive | Positive_clone | F54E7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 5250 | |||||
5049 | |||||||
Pseudo_map_position | |||||||
Reference (25) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |