WormBase Tree Display for Gene: WBGene00004210
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WBGene00004210 | Evidence | CGC_data_submission | ||||
---|---|---|---|---|---|---|
SMap | S_parent | Sequence | Y110A2AL | |||
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | ptc | |||||
Allele (195) | ||||||
RNASeq_FPKM (74) | ||||||
GO_annotation (14) | ||||||
Ortholog (41) | ||||||
Paralog (31) | ||||||
Structured_description | Concise_description | ptc-3 encodes an ortholog of Drosophila PATCHED (PTC) and human PTCH(OMIM:601309, mutated in basal cell nevus syndrome), which defines oneof seven paralogous families of sterol sensing domain (SSD) proteins;PTC-3 is strongly required for normal molting from L1 to L3 larvalstages; PTC-3 is also required for normal growth to full size and forviability. | Paper_evidence | WBPaper00004265 | ||
WBPaper00026841 | ||||||
WBPaper00027263 | ||||||
Curator_confirmed | WBPerson567 | |||||
Date_last_updated | 08 Nov 2006 00:00:00 | |||||
Automated_description | Predicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Involved in molting cycle. Located in apical plasma membrane and cytoplasmic vesicle. Expressed in several structures, including CEP; cloaca; egg-laying apparatus; excretory duct; and preanal ganglion. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal adenoma; and holoprosencephaly 7. Is an ortholog of human PTCH1 (patched 1) and PTCH2 (patched 2). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Disease_info | Potential_model (18) | |||||
Molecular_info | Corresponding_CDS | Y110A2AL.8a | ||||
Y110A2AL.8b | ||||||
Y110A2AL.8c | ||||||
Corresponding_CDS_history (2) | ||||||
Corresponding_transcript | Y110A2AL.8a.1 | |||||
Y110A2AL.8b.1 | ||||||
Y110A2AL.8c.1 | ||||||
Other_sequence (34) | ||||||
Associated_feature (13) | ||||||
Experimental_info | RNAi_result (14) | |||||
Expr_pattern | Expr9231 | |||||
Expr9232 | ||||||
Expr1017786 | ||||||
Expr1032067 | ||||||
Expr1158842 | ||||||
Expr2015145 | ||||||
Expr2033383 | ||||||
Drives_construct | WBCnstr00008494 | |||||
WBCnstr00008496 | ||||||
WBCnstr00035634 | ||||||
Construct_product | WBCnstr00008494 | |||||
WBCnstr00008495 | ||||||
WBCnstr00008496 | ||||||
WBCnstr00008497 | ||||||
WBCnstr00008498 | ||||||
WBCnstr00008502 | ||||||
WBCnstr00035634 | ||||||
Antibody | WBAntibody00002998 | |||||
Microarray_results (31) | ||||||
Expression_cluster (200) | ||||||
Interaction (78) | ||||||
WBProcess | WBbiopr:00000123 | |||||
Map_info (3) | ||||||
Reference (21) | ||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||
Method | Gene |