WormBase Tree Display for Gene: WBGene00003936
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| WBGene00003936 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | pat-12 | Person_evidence | WBPerson1562 | |||||
| WBPerson3826 | |||||||||
| WBPerson1579 | |||||||||
| Sequence_name | T17H7.4 | ||||||||
| Molecular_name (41) | |||||||||
| Other_name | gei-16 | Person_evidence | WBPerson1796 | ||||||
| CELE_T17H7.4 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | pat-12 | ||||||||
| DB_info | Database | WormFlux | gene | WBGene00003936 | |||||
| NDB | locus_tag | CELE_T17H7.4 | |||||||
| NCBI | gene | 175227 | |||||||
| RefSeq | protein (11) | ||||||||
| SwissProt | UniProtAcc | Q95QA6 | |||||||
| TrEMBL | UniProtAcc | A0A2K5ATV2 | |||||||
| UniProt_GCRP | UniProtAcc | Q95QA6 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 11 Jan 2010 11:56:54 | WBPerson2970 | Event | Acquires_merge | WBGene00001573 | ||||
| Name_change | Other_name | gei-16 | |||||||
| Acquires_merge | WBGene00001573 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pat | ||||||||
| Allele (564) | |||||||||
| Legacy_information | [Williams BD] Mild Pat phenotype; some pharyngeal pumping. | ||||||||
| [C.elegansII] st430 : mild Pat phenotype; some pharyngeal pumping. [Williams and Waterston 1994; RW] | |||||||||
| Strain | WBStrain00033497 | ||||||||
| WBStrain00035847 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (26) | |||||||||
| Structured_description | Concise_description | pat-12 encodes several isoforms containing a novel hemidesmosome component that has strong homology to antigen B20 from filarial nematode onchocerca volvulus, which partly protects different hosts against infection when used for immunization; PAT-12 activity is important to maintain FO integrity and might have distinct functions apically and basally based on differential loss of VAB-10A, CIFs and ECM receptors at the two plasma membrane; in pat-12 mutants muscles reach their normal position but fail to maintain them once they start to contract suggesting CeHDs are defective; epidermal integrity is lost in pat-12 mutants resulting from internal rupture; PAT-12A localization depends another fibrous organelle components; PAT-12 function is dispensable for feeding, fertilization and egg-laying; pat-12 expression is complex with isoforms A, E, J, K being fibrous organelle components: the isoforms A and J are in pharyngeal and epidermal FOs; during late embryogenesis, PAT-12K colocalizes with junctions between seam cells and epidermal cells, PAT-12E/F/I is detected in spermatheca plasma membrane, weakly in vulva; are present where cIFs are located. | Paper_evidence | WBPaper00037850 | |||||
| Curator_confirmed | WBPerson12884 | ||||||||
| Date_last_updated | 17 Jun 2011 00:00:00 | ||||||||
| Automated_description | Involved in embryonic morphogenesis and hemidesmosome assembly. Located in hemidesmosome. Expressed in head neurons; mechanosensory neurons; rectum; seam cell; and spermatheca. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS (11) | ||||||||
| Corresponding_CDS_history | T17H7.4f:wp277 | ||||||||
| T17H7.4l:wp275 | |||||||||
| Corresponding_transcript (19) | |||||||||
| Other_sequence (62) | |||||||||
| Associated_feature (26) | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern | Chronogram29 | ||||||||
| Expr6705 | |||||||||
| Expr11568 | |||||||||
| Expr11569 | |||||||||
| Expr11570 | |||||||||
| Expr11571 | |||||||||
| Expr1031868 | |||||||||
| Expr1157027 | |||||||||
| Expr2014749 | |||||||||
| Expr2032983 | |||||||||
| Drives_construct | WBCnstr00003743 | ||||||||
| WBCnstr00008091 | |||||||||
| WBCnstr00008092 | |||||||||
| WBCnstr00008093 | |||||||||
| WBCnstr00008094 | |||||||||
| WBCnstr00008095 | |||||||||
| WBCnstr00008096 | |||||||||
| WBCnstr00008097 | |||||||||
| WBCnstr00008098 | |||||||||
| WBCnstr00008099 | |||||||||
| Construct_product | WBCnstr00008091 | ||||||||
| WBCnstr00008092 | |||||||||
| WBCnstr00008093 | |||||||||
| WBCnstr00008094 | |||||||||
| WBCnstr00008095 | |||||||||
| Microarray_results (105) | |||||||||
| Expression_cluster (208) | |||||||||
| Interaction (547) | |||||||||
| WBProcess | WBbiopr:00000006 | ||||||||
| Map_info | Map | III | Position | -26.2422 | Error | 0.011603 | |||
| Positive | Positive_clone | T17H7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3023 | |||||||
| 4612 | |||||||||
| Reference (19) | |||||||||
| Remark | Data extracted from Williams & Waterston 1994 | ||||||||
| Method | Gene |
