WormBase Tree Display for Gene: WBGene00003829
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WBGene00003829 | SMap | S_parent | Sequence | F53A2 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | nud | ||||||
Allele (18) | |||||||
Strain | WBStrain00035169 | ||||||
WBStrain00031486 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (15) | |||||||
Contained_in_operon | CEOP3784 | ||||||
Ortholog (36) | |||||||
Structured_description | Concise_description | nud-1 encodes the C. elegans ortholog of the Aspergillus nidulans nudC, which mediates nuclear migration along Aspergillus hyphae. | Paper_evidence | WBPaper00004895 | |||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables identical protein binding activity and unfolded protein binding activity. Involved in several processes, including GABAergic synaptic transmission; chaperone-mediated protein folding; and establishment of organelle localization. Predicted to be located in cytoplasm. Expressed in gonad; hypodermis; intestine; and neurons. Used to study epilepsy and lissencephaly. Is an ortholog of human NUDC (nuclear distribution C, dynein complex regulator). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00028525 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 24 Aug 2021 00:00:00 | ||||||
DOID:0050453 | Homo sapiens | Paper_evidence | WBPaper00028525 | ||||
Accession_evidence | OMIM | 607432 | |||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 17 Apr 2013 00:00:00 | ||||||
Disease_relevance | In humans, mutations in the LIS1 gene (Platelet activating factor acetylhydrolase, isoform 1B, alpha subunit; PAFAH1B1) and the LIS1 pathway, are implicated in Lissencephaly, a developmental abnormality associated with a failure of neuronal migration in the cerebral cortex, leading to mental retardation and epilepsy; human NDE1 and NDEL1, are effectors of LIS1; the elegans genetic model for epileptic siezures consists of lis-1 mutants that are responsive to the common seizure inducer pentylenetetrazole (PTZ) and diplay a distinct convulsive phenotype; worms depleted for LIS1 pathway components via RNA interference (NUD-1, NUD-2, DHC-1, CDK-5, and CDKA-1) also exhibited significant convulsions following PTZ treatment; further nud-1 (orthologous to human NUDC), nud-2/NDE1 and cdk-5 show significant enhancement in convulsions in a lis-1 heterozygous background when compared with the wild-type background; these animals are also less likely to recover when PTZ treatment is removed, when compared to wild-type; these studies show that while knocking down target genes (lis-1, cdk-5, and cdka-1 that function in neuronal migration), and their interacting proteins like nud-1, nud-2 and dhc-1, does not yield spontaneous convulsions in C. elegans, further alterations in the neural environment through the application of PTZ serve to pass a critical threshold within these animals. | Homo sapiens | Paper_evidence | WBPaper00024523 | |||
WBPaper00028525 | |||||||
Accession_evidence | OMIM | 601545 | |||||
Curator_confirmed | WBPerson324 | ||||||
Models_disease_in_annotation | WBDOannot00000148 | ||||||
WBDOannot00001010 | |||||||
Molecular_info (4) | |||||||
Experimental_info | RNAi_result (22) | ||||||
Expr_pattern | Expr2419 | ||||||
Expr10134 | |||||||
Expr1011738 | |||||||
Expr1031804 | |||||||
Expr1151858 | |||||||
Expr2014524 | |||||||
Expr2032763 | |||||||
Drives_construct | WBCnstr00000117 | ||||||
Construct_product | WBCnstr00007338 | ||||||
Microarray_results (20) | |||||||
Expression_cluster (141) | |||||||
Interaction (45) | |||||||
Map_info | Map | III | Position | 21.2108 | Error | 0.000119 | |
Positive | Positive_clone | F53A2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4503 | |||||
4549 | |||||||
Pseudo_map_position | |||||||
Reference (23) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |