WormBase Tree Display for Gene: WBGene00003576
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WBGene00003576 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | ndc-80 | Person_evidence | WBPerson283 | |||
Sequence_name | W01B6.9 | ||||||
Molecular_name | W01B6.9 | ||||||
W01B6.9.1 | |||||||
CE06537 | |||||||
Other_name | cogc-7 | Paper_evidence | WBPaper00026979 | ||||
Person_evidence | WBPerson449 | ||||||
CELE_W01B6.9 | Accession_evidence | NDB | BX284604 | ||||
Public_name | ndc-80 | ||||||
DB_info | Database (10) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ndc | ||||||
Allele (30) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (38) | |||||||
Ortholog (30) | |||||||
Structured_description | Concise_description | ndc-80 (cogc-7) encodes an ortholog of mammalian COG-7 (OMIM:606978,mutated in congenital disorder of glycosylation), a subunit of lobe B ofthe conserved oligomeric Golgi complex (COGC); NDC-80 is also an outerkinetochore component orthologous to S. cerevisiae Ndc80p; NDC-80 affectsmetaphase plate formation in embryos (thus affecting chromosomesegregation), kinetochore-microtubule interactions, locomotion, vulvaldevelopment, body morphology, and embryonic viability; NDC-80 is weaklyrequired for normal gonadal distal tip cell migration, a process that alsorequires seven other orthologs of COGC subunits; like other lobe Bsubunits in both C. elegans and S. cerevisiae, NDC-80 is only partiallyrequired for normal function, while lobe A subunits are strongly requiredin either worms or yeast; NDC-80 interacts in vivo with KNL-1, HIM-10, anda homolog of Nuf2p, and NDC-80 and HIM-10 are codependent for kinetochoreassembly. | Paper_evidence | WBPaper00005330 | |||
WBPaper00005654 | |||||||
WBPaper00006142 | |||||||
WBPaper00006309 | |||||||
WBPaper00026979 | |||||||
WBPaper00028363 | |||||||
WBPaper00028599 | |||||||
WBPaper00028601 | |||||||
WBPaper00028602 | |||||||
WBPaper00028603 | |||||||
Curator_confirmed | WBPerson48 | ||||||
WBPerson567 | |||||||
Date_last_updated | 25 Oct 2006 00:00:00 | ||||||
Automated_description | Enables protein domain specific binding activity. Involved in several processes, including chromosome organization; gonad morphogenesis; and positive regulation of kinetochore assembly. Located in kinetochore. Part of Ndc80 complex. Human ortholog(s) of this gene implicated in colorectal cancer; lung non-small cell carcinoma; and stomach cancer. Is an ortholog of human NDC80 (NDC80 kinetochore complex component). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16909) | ||
DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16909) | ||||
DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16909) | ||||
Molecular_info | Corresponding_CDS | W01B6.9 | |||||
Corresponding_transcript | W01B6.9.1 | ||||||
Other_sequence | FG618964.1 | ||||||
CR01998 | |||||||
CBC04689_1 | |||||||
CR03902 | |||||||
CJC17913_1 | |||||||
CRC01587_1 | |||||||
CJC07860_1 | |||||||
Associated_feature | WBsf646280 | ||||||
WBsf660549 | |||||||
WBsf228926 | |||||||
WBsf228927 | |||||||
WBsf228928 | |||||||
Experimental_info | RNAi_result (17) | ||||||
Expr_pattern | Expr3437 | ||||||
Expr1017660 | |||||||
Expr1031629 | |||||||
Expr1158057 | |||||||
Expr2013927 | |||||||
Expr2032166 | |||||||
Drives_construct | WBCnstr00018541 | ||||||
WBCnstr00018542 | |||||||
WBCnstr00018543 | |||||||
WBCnstr00018544 | |||||||
WBCnstr00018545 | |||||||
WBCnstr00018553 | |||||||
WBCnstr00036029 | |||||||
Construct_product | WBCnstr00018541 | ||||||
WBCnstr00018542 | |||||||
WBCnstr00018543 | |||||||
WBCnstr00018544 | |||||||
WBCnstr00018545 | |||||||
WBCnstr00018553 | |||||||
WBCnstr00036029 | |||||||
Antibody | WBAntibody00000992 | ||||||
Microarray_results (22) | |||||||
Expression_cluster (160) | |||||||
Interaction (97) | |||||||
Map_info | Map | IV | Position | 4.49123 | Error | 0.003102 | |
Positive | Positive_clone | W01B6 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Pseudo_map_position | |||||||
Reference (25) | |||||||
Remark | Sequence connection from [Oegema K, Hyman AA] [090402 ck1] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |