WormBase Tree Display for Gene: WBGene00002233
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WBGene00002233 | SMap | S_parent | Sequence | C25B8 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | kqt-1 | Person_evidence | WBPerson655 | |||||
Sequence_name | C25B8.1 | ||||||||
Molecular_name | C25B8.1a | ||||||||
C25B8.1a.1 | |||||||||
CE27086 | |||||||||
C25B8.1b | |||||||||
CE30875 | |||||||||
C25B8.1b.1 | |||||||||
Other_name | klq-1 | ||||||||
CELE_C25B8.1 | Accession_evidence | NDB | BX284606 | ||||||
Public_name | kqt-1 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | kqt | ||||||||
Allele (129) | |||||||||
Strain | WBStrain00036366 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (21) | |||||||||
Ortholog (48) | |||||||||
Paralog (13) | |||||||||
Structured_description (2) | |||||||||
Disease_info | Experimental_model | DOID:2843 | Homo sapiens | Paper_evidence | WBPaper00025059 | ||||
Accession_evidence | OMIM | 192500 | |||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 07 May 2012 00:00:00 | ||||||||
DOID:0112202 | Homo sapiens | Paper_evidence | WBPaper00025059 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 07 May 2012 00:00:00 | ||||||||
Potential_model | DOID:0110558 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6298) | |||||
DOID:14264 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6296,HGNC:6297) | ||||||
DOID:0080237 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6299) | ||||||
DOID:10003 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6298) | ||||||
DOID:12849 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6297) | ||||||
DOID:0080462 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6296) | ||||||
Disease_relevance | The kqt genes in elegans (kqt-1, kqt-2, kqt-3) are most similar to the human KCNQ multi-gene family encoding potassium channels; C. elegans kqt-1 defines a subfamily of potassium channel genes along with the human KCNQ2-5 and kqt-3 is most similar to KCNQ1; mutations in human KCNQ genes have been associated with genetic disorders of cardiac arrhythmia and deafness; mutations in KCNQ2 are involved in epileptic encephalopathy (early infantile 7), Myokymia and seizures (benign neonatal 1), mutations in KCNQ3 are associated with neonatal seizures (benign neonatal 2), and those in KCNQ4 are associated with deafness (autosomal dominant 2A); studies in elegans show that the suppression of KCNQ/KQT channels by diacylglycerol (DAG) is dependent on the carboxyl terminal domains of the channel subunits and activated protein kinase C. | Homo sapiens | Paper_evidence | WBPaper00025059 | |||||
Accession_evidence | OMIM | 613720 | |||||||
121200 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 07 May 2012 00:00:00 | ||||||||
Models_disease_in_annotation (2) | |||||||||
Molecular_info | Corresponding_CDS | C25B8.1a | |||||||
C25B8.1b | |||||||||
Corresponding_transcript | C25B8.1a.1 | ||||||||
C25B8.1b.1 | |||||||||
Other_sequence | MJC02896_1 | ||||||||
MJ00417 | |||||||||
BMC10934_1 | |||||||||
JI172162.1 | |||||||||
JI174705.1 | |||||||||
JI219469.1 | |||||||||
Associated_feature (20) | |||||||||
Experimental_info | RNAi_result | WBRNAi00041161 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00001487 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00075817 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00041162 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00011145 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00041160 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr3234 | ||||||||
Expr1018104 | |||||||||
Expr1031310 | |||||||||
Expr1145191 | |||||||||
Expr2012976 | |||||||||
Expr2031208 | |||||||||
Drives_construct | WBCnstr00011240 | ||||||||
WBCnstr00036369 | |||||||||
Construct_product | WBCnstr00011240 | ||||||||
WBCnstr00036369 | |||||||||
Microarray_results (26) | |||||||||
Expression_cluster (146) | |||||||||
Interaction | WBInteraction000169452 | ||||||||
WBInteraction000173470 | |||||||||
WBInteraction000264869 | |||||||||
WBInteraction000301540 | |||||||||
WBInteraction000544613 | |||||||||
WBInteraction000578572 | |||||||||
Map_info | Map | X | Position | -2.69956 | Error | 0.014064 | |||
Positive | Positive_clone | C25B8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4237 | |||||||
Pseudo_map_position | |||||||||
Reference (12) | |||||||||
Picture | WBPicture0000013535 | ||||||||
Remark | Sequence connection from [Thomas JH, Wei A] | ||||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
Method | Gene |