WormBase Tree Display for Gene: WBGene00001707
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| WBGene00001707 | Evidence | Author_evidence | Venkatesan K | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y48G8AR | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | grh-1 | |||||||
| Sequence_name | Y48G8AR.1 | ||||||||
| Molecular_name | Y48G8AR.1a | ||||||||
| Y48G8AR.1a.1 | |||||||||
| CE34614 | |||||||||
| Y48G8AR.1b | |||||||||
| CE49585 | |||||||||
| Y48G8AR.1c | |||||||||
| CE49548 | |||||||||
| Y48G8AR.1b.1 | |||||||||
| Y48G8AR.1c.1 | |||||||||
| Other_name | Y48G8AR.a | Curator_confirmed | WBPerson1983 | ||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| Y48G8AR.b | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_Y48G8AR.1 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | grh-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | grh | ||||||||
| Allele (189) | |||||||||
| Possibly_affected_by | WBVar02158847 | ||||||||
| Strain | WBStrain00003294 | ||||||||
| WBStrain00037063 | |||||||||
| WBStrain00033869 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (45) | |||||||||
| Structured_description | Concise_description | grh-1 encodes a LSF/GRH transcription factor homolog required for normal cuticular synthesis and embryonic development; both GRH-1 and its Drosophila homolog GRAINYHEAD bind to DNA sites upstream of dbl-1, mab-5, and tdc-1; all three of these target genes are homologs of genes regulated by GRAINYHEAD in Drosophila; grh-1(RNAi) animals die as embryos with soft, defective cuticles, which resembles the phenotype seen in Drosophila grainyhead mutants. | Paper_evidence | WBPaper00006017 | |||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables sequence-specific double-stranded DNA binding activity. Involved in defense response to bacterium; determination of adult lifespan; and ecdysis, collagen and cuticulin-based cuticle. Located in nucleus. Part of chromatin. Expressed in head neurons; hypodermal cell; pharyngeal cell; seam cell; and vulval precursor cell. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Is an ortholog of human GRHL1 (grainyhead like transcription factor 1); GRHL2 (grainyhead like transcription factor 2); and GRHL3 (grainyhead like transcription factor 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080669 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2799) | ||||
| DOID:0110557 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2799) | ||||||
| Molecular_info | Corresponding_CDS | Y48G8AR.1a | |||||||
| Y48G8AR.1b | |||||||||
| Y48G8AR.1c | |||||||||
| Corresponding_CDS_history | Y48G8AR.1:wp102 | ||||||||
| Corresponding_transcript | Y48G8AR.1a.1 | ||||||||
| Y48G8AR.1b.1 | |||||||||
| Y48G8AR.1c.1 | |||||||||
| Other_sequence (74) | |||||||||
| Associated_feature (18) | |||||||||
| Gene_product_binds | WBsf019102 | ||||||||
| WBsf019103 | |||||||||
| Transcription_factor | WBTranscriptionFactor000097 | ||||||||
| Experimental_info | RNAi_result (44) | ||||||||
| Expr_pattern | Chronogram246 | ||||||||
| Expr2620 | |||||||||
| Expr7013 | |||||||||
| Expr16391 | |||||||||
| Expr1028043 | |||||||||
| Expr1031020 | |||||||||
| Expr1160422 | |||||||||
| Expr2012241 | |||||||||
| Expr2030477 | |||||||||
| Drives_construct | WBCnstr00003765 | ||||||||
| WBCnstr00042836 | |||||||||
| Construct_product | WBCnstr00042698 | ||||||||
| WBCnstr00042836 | |||||||||
| Regulate_expr_cluster | WBPaper00062344:grh-1(overexpression)_upregulated | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (151) | |||||||||
| Interaction (19) | |||||||||
| Map_info | Map | I | Position | -15.4628 | Error | 0.362048 | |||
| Positive | Positive_clone | Y48G8AR | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00006017 | ||||||||
| WBPaper00027309 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00050218 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00059477 | |||||||||
| WBPaper00062344 | |||||||||
| WBPaper00064339 | |||||||||
| WBPaper00064942 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
