WormBase Tree Display for Gene: WBGene00001137
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| WBGene00001137 | SMap | S_parent | Sequence | B0365 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | eat-6 | Person_evidence | WBPerson32 | |||||
| Sequence_name | B0365.3 | ||||||||
| Molecular_name | B0365.3 | ||||||||
| B0365.3.1 | |||||||||
| CE07721 | |||||||||
| B0365.3.2 | |||||||||
| Other_name | NaK/1 | ||||||||
| spa-1 | |||||||||
| CELE_B0365.3 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | eat-6 | ||||||||
| DB_info | Database | AceView | gene | 5N608 | |||||
| WormQTL | gene | WBGene00001137 | |||||||
| WormFlux | gene | WBGene00001137 | |||||||
| NDB | locus_tag | CELE_B0365.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00001137|UniProtKB=P90735 | |||||||
| family | PTHR43294 | ||||||||
| NCBI | gene | 179796 | |||||||
| RefSeq | protein | NM_073868.6 | |||||||
| TrEMBL | UniProtAcc | P90735 | |||||||
| UniProt_GCRP | UniProtAcc | P90735 | |||||||
| OMIM | gene | 182310 | |||||||
| 182340 | |||||||||
| 182350 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:23 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | eat | ||||||||
| Allele (46) | |||||||||
| Legacy_information (3) | |||||||||
| Strain | WBStrain00036106 | ||||||||
| WBStrain00037778 | |||||||||
| WBStrain00005464 | |||||||||
| WBStrain00005489 | |||||||||
| WBStrain00005507 | |||||||||
| WBStrain00005516 | |||||||||
| WBStrain00005529 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (36) | |||||||||
| Ortholog (46) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | eat-6 encodes an ortholog of the alpha subunit of a sodium/potassium ATPase, which in turn affects Na+,K(+)-ATPase activity of membranes by affecting the level of the phosphorylated intermediate of the Na+,K(+)-ATPase; EAT-6 affects relaxation of the pharyngeal muscles, fertility (and thus affects feeding); EAT-6 also affects body length, life span, and ASE, ASI and ASJ axonal outgrowth. | Paper_evidence | WBPaper00001709 | |||||
| WBPaper00002371 | |||||||||
| WBPaper00003150 | |||||||||
| WBPaper00003257 | |||||||||
| WBPaper00003521 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson363 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables P-type sodium:potassium-exchanging transporter activity. Involved in several processes, including action potential; monoatomic ion transport; and regulation of muscle contraction. Located in membrane. Expressed in several structures, including coelomocyte; intestine; neurons; pharynx; and vulval muscle. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2DD; alternating hemiplegia of childhood; and brain disease (multiple). Is an ortholog of human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00045914 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Jun 2019 00:00:00 | ||||||||
| Potential_model (12) | |||||||||
| Models_disease_asserted | WBDOannot00000704 | ||||||||
| Molecular_info | Corresponding_CDS | B0365.3 | |||||||
| Corresponding_transcript | B0365.3.1 | ||||||||
| B0365.3.2 | |||||||||
| Other_sequence (276) | |||||||||
| Associated_feature (18) | |||||||||
| Experimental_info | RNAi_result (34) | ||||||||
| Expr_pattern | Expr8226 | ||||||||
| Expr8228 | |||||||||
| Expr12845 | |||||||||
| Expr1017676 | |||||||||
| Expr1030726 | |||||||||
| Expr1143152 | |||||||||
| Expr2011160 | |||||||||
| Expr2029396 | |||||||||
| Drives_construct | WBCnstr00013194 | ||||||||
| WBCnstr00022897 | |||||||||
| WBCnstr00037068 | |||||||||
| Construct_product | WBCnstr00013192 | ||||||||
| WBCnstr00037068 | |||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (174) | |||||||||
| Interaction (116) | |||||||||
| Map_info | Map | V | Position | 4.93766 | Error | 0.013547 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | B0365 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| DF#NK1 | |||||||||
| R07B8 | |||||||||
| Mapping_data | 2_point | 5213 | |||||||
| Multi_point | 1837 | ||||||||
| 1839 | |||||||||
| 1840 | |||||||||
| 1841 | |||||||||
| 2403 | |||||||||
| 2404 | |||||||||
| 3844 | |||||||||
| 4482 | |||||||||
| Pos_neg_data (4) | |||||||||
| Reference (55) | |||||||||
| Remark | [MW Davis] Transformation rescue. | ||||||||
| Method | Gene |
