WormBase Tree Display for Gene: WBGene00000787
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WBGene00000787 | Evidence | CGC_data_submission | ||||
---|---|---|---|---|---|---|
SMap | S_parent | Sequence | C41D11 | |||
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | cps | |||||
Allele (33) | ||||||
Legacy_information | Recessive mutation sm116 weakly suppresses neuronal cell deaths and enhances suppression by ced-8(n1891). Encodes mitochondrial endonuclease G. | |||||
Strain | WBStrain00036451 | |||||
RNASeq_FPKM (74) | ||||||
GO_annotation (34) | ||||||
Contained_in_operon | CEOP1180 | |||||
Ortholog (36) | ||||||
Structured_description | Concise_description | cps-6 encodes an ortholog of human mitochondrial endonuclease G (EndoG) that promotes apoptosis, and is required to degrade nicked (TUNEL-positive) DNA in apoptotic cells; transgenic CPS-6 is localized to mitochondria, but transgenic CPS-6 lacking a mitochondrial localization sequence is found in nuclei, and nuclei may be the in vivo target of CPS-6 after its activation by CED-3; CPS-6 has magnesium-dependent nuclease activity in vitro and can degrade both single- and double-stranded DNA, as well as single-stranded RNA; CPS-6 also preferentially binds G-tract DNA in vitro; cps-6(sm116) and cps-6(RNAi) animals have delayed CED-3-induced apoptosis, and cps-6(sm116) suppresses a constitutively active ced-3 transgene; cps-6(sm116) can be transgenically rescued by mouse EndoG; CPS-6 binds WAH-1 (an apoptosis-inducing factor ortholog) in vitro, WAH-1 binding enhances CPS-6's endonuclease activity, and constitutive transgenic coexpression of cps-6 with wah-1 induces cell death not seen with constitutive expression of either cps-6 or wah-1 alone; CPS-6 binds CRN-1 (a flap endonuclease ortholog) in vitro, and may form a large complex in vivo with CRN-1, CRN-4, CRN-5, CYP-13, and WAH-1; CRN-1 enhances CPS-6's endonuclease activity in vitro, CPS-6 enhances CRN-1's gap-dependent endonuclease and 5'-3' exonuclease activities, and cps-6 is required for excess cell deaths induced by a crn-1 transgene. | Paper_evidence | WBPaper00004743 | ||
WBPaper00005558 | ||||||
WBPaper00005857 | ||||||
WBPaper00005978 | ||||||
WBPaper00028402 | ||||||
WBPaper00040583 | ||||||
Curator_confirmed | WBPerson567 | |||||
Date_last_updated | 17 Feb 2012 00:00:00 | |||||
Automated_description | Enables endonuclease activity; protein homodimerization activity; and sequence-specific DNA binding activity. Involved in RNA catabolic process and apoptotic DNA fragmentation. Located in mitochondrion. Is an ortholog of human ENDOG (endonuclease G). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Molecular_info | Corresponding_CDS | C41D11.8 | ||||
Corresponding_transcript | C41D11.8.1 | |||||
Other_sequence (38) | ||||||
Associated_feature | WBsf219272 | |||||
Experimental_info | RNAi_result | WBRNAi00005011 | Inferred_automatically | RNAi_primary | ||
WBRNAi00087543 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00097790 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00097791 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00042291 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00097793 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00097792 | Inferred_automatically | RNAi_primary | ||||
Expr_pattern | Expr1493 | |||||
Expr1015388 | ||||||
Expr1030488 | ||||||
Expr1146282 | ||||||
Expr2010509 | ||||||
Expr2028749 | ||||||
Construct_product | WBCnstr00010306 | |||||
Antibody | WBAntibody00002303 | |||||
Microarray_results (19) | ||||||
Expression_cluster (138) | ||||||
Interaction (109) | ||||||
WBProcess | WBbiopr:00000014 | |||||
WBbiopr:00000103 | ||||||
WBbiopr:00000106 | ||||||
Map_info (4) | ||||||
Reference (25) | ||||||
Remark | Data extracted from Parrish et al (2001) | |||||
Sequence connection updated to C41D11.8 based on email from Jean & Danielle and John Spieth (citing GenBank AF390558) | ||||||
Method | Gene |