WormBase Tree Display for Gene: WBGene00000544
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| WBGene00000544 | SMap | S_parent | Sequence | Y47H10A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | clp-3 | Person_evidence | WBPerson349 | |||||
| Sequence_name | Y47H10A.1 | ||||||||
| Molecular_name | Y47H10A.1 | ||||||||
| Y47H10A.1.1 | |||||||||
| CE50288 | |||||||||
| Other_name | CELE_Y47H10A.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | clp-3 | ||||||||
| DB_info | Database | AceView | gene | 1M666 | |||||
| WormQTL | gene | WBGene00000544 | |||||||
| WormFlux | gene | WBGene00000544 | |||||||
| NDB | locus_tag | CELE_Y47H10A.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00000544|UniProtKB=Q9U2B2 | |||||||
| family | PTHR10183 | ||||||||
| NCBI | gene | 173089 | |||||||
| RefSeq | protein | NM_060651.7 | |||||||
| TrEMBL | UniProtAcc | Q9U2B2 | |||||||
| UniProt_GCRP | UniProtAcc | Q9U2B2 | |||||||
| OMIM | gene | 114220 | |||||||
| 114240 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:21 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | clp | ||||||||
| Allele (195) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00098998 | ||||||||
| 00098999 | |||||||||
| 00099000 | |||||||||
| 00099001 | |||||||||
| 00107571 | |||||||||
| 00107572 | |||||||||
| Ortholog (40) | |||||||||
| Paralog (13) | |||||||||
| Structured_description | Concise_description | clp-3 encodes an atypical calpain, which is a calcium regulated thiol protease; clp-3 is orthologous to the human calpains, that include CAPN1, CAPN11 and CAPN12; reducing the function of clp-3 via RNAi did not yield any obvious phenotypes, possibly due to functional redundancy among clp genes in C. elegans. | Paper_evidence | WBPaper00005513 | |||||
| WBPaper00040962 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 02 Apr 2013 00:00:00 | ||||||||
| Automated_description | Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; hereditary spastic paraplegia 76; and stomach cancer. Is an ortholog of several human genes including CAPN1 (calpain 1); CAPN2 (calpain 2); and CAPN3 (calpain 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1476,HGNC:1479) | ||||
| DOID:0110275 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1480) | ||||||
| DOID:0110273 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1480) | ||||||
| DOID:9884 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1480) | ||||||
| DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1486) | ||||||
| DOID:0110821 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1476) | ||||||
| Molecular_info | Corresponding_CDS | Y47H10A.1 | |||||||
| Corresponding_CDS_history | Y47H10A.1:wp159 | ||||||||
| Y47H10A.1:wp245 | |||||||||
| Corresponding_transcript | Y47H10A.1.1 | ||||||||
| Associated_feature | WBsf985465 | ||||||||
| WBsf985466 | |||||||||
| WBsf985467 | |||||||||
| WBsf985468 | |||||||||
| WBsf1010834 | |||||||||
| WBsf1010835 | |||||||||
| WBsf1010836 | |||||||||
| WBsf1010837 | |||||||||
| WBsf220395 | |||||||||
| WBsf220396 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00022738 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00022736 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00056830 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00022737 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00004653 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00007364 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1010660 | ||||||||
| Expr1160288 | |||||||||
| Expr2010245 | |||||||||
| Expr2028487 | |||||||||
| Drives_construct | WBCnstr00014647 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (125) | |||||||||
| Map_info | Map | I | Position | 13.0472 | Error | 0.003696 | |||
| Positive | Positive_clone | Y47H10A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00005513 | ||||||||
| WBPaper00027531 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Sequence connection from [Kuwabara PE] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
