WormBase Tree Display for Gene: WBGene00000516
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WBGene00000516 | SMap | S_parent | Sequence | T05A6 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | cki | ||||||
Allele (11) | |||||||
Strain | WBStrain00035555 | ||||||
WBStrain00050664 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (22) | |||||||
Ortholog (25) | |||||||
Paralog | WBGene00000517 | Caenorhabditis elegans | From_analysis | TreeFam | |||
WormBase-Compara | |||||||
Structured_description | Concise_description | cki-1 encodes a homolog of the mammalian cyclin-dependent kinase inhibitor p27/KIP1 that is required for the arrest of cell division in larval blast lineages, dauer larvae and starved L1 larvae; excess CKI-1 expression prematurely stops cell division while cki-1(RNAi) induces extra cell divisions, indicating that CKI-1 quantitatively regulates the amount of mitosis in postembryonic worms. | Paper_evidence | WBPaper00003201 | |||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Predicted to enable cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including gonad development; regulation of cell cycle process; and regulation of cell division. Located in nucleus. Expressed in several structures, including excretory duct; hermaphrodite somatic gonadal cell; hypodermal cell; pharynx; and somatic gonad precursor. Human ortholog(s) of this gene implicated in several diseases, including hematologic cancer (multiple); lung carcinoma (multiple); and urinary system cancer (multiple). Is an ortholog of human CDKN1B (cyclin dependent kinase inhibitor 1B). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (15) | ||||||
Molecular_info | Corresponding_CDS | T05A6.1 | |||||
Corresponding_transcript | T05A6.1.1 | ||||||
Other_sequence | AF179358 | ||||||
CJC06215_1 | |||||||
Associated_feature (24) | |||||||
Experimental_info | RNAi_result (52) | ||||||
Expr_pattern (13) | |||||||
Drives_construct (5) | |||||||
Construct_product | WBCnstr00000595 | ||||||
WBCnstr00015480 | |||||||
WBCnstr00019394 | |||||||
WBCnstr00021185 | |||||||
WBCnstr00037482 | |||||||
WBCnstr00041722 | |||||||
Antibody | WBAntibody00000980 | ||||||
Microarray_results (21) | |||||||
Expression_cluster (249) | |||||||
Interaction (109) | |||||||
Map_info | Map | II | Position | 0.566619 | Error | 0.001788 | |
Positive | Positive_clone | T05A6 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4221 | |||||
4222 | |||||||
Pseudo_map_position | |||||||
Reference (120) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |