WormBase Tree Display for Gene: WBGene00000467
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WBGene00000467 | SMap | S_parent | Sequence | F52B5 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | cep-1 | Person_evidence | WBPerson539 | |||||
Sequence_name | F52B5.5 | ||||||||
Molecular_name | F52B5.5a | ||||||||
F52B5.5a.1 | |||||||||
CE29805 | |||||||||
F52B5.5b | |||||||||
CE38369 | |||||||||
F52B5.5b.1 | |||||||||
F52B5.5b.2 | |||||||||
F52B5.5b.3 | |||||||||
F52B5.5b.4 | |||||||||
Other_name | CELE_F52B5.5 | Accession_evidence | NDB | BX284601 | |||||
Public_name | cep-1 | ||||||||
DB_info | Database (7) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | cep | ||||||||
Allele (54) | |||||||||
Strain | WBStrain00022753 | ||||||||
WBStrain00034662 | |||||||||
WBStrain00034663 | |||||||||
WBStrain00034811 | |||||||||
WBStrain00035557 | |||||||||
WBStrain00040683 | |||||||||
WBStrain00004786 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (45) | |||||||||
Ortholog (17) | |||||||||
Structured_description | Concise_description | cep-1 encodes an ortholog of the human tumor suppressor p53 (OMIM:191170, mutated in Li-Fraumeni syndrome) that promotes DNA damage-induced apoptosis and is required for normal meiotic segregation in the germ line, and affects sensitivity to hypoxia-induced lethality and longevity in response to starvation; CEP-1 is expressed ubiquitously in embryos and in the nucleoli of a subset of pharyngeal cells. | Paper_evidence | WBPaper00004589 | |||||
WBPaper00004919 | |||||||||
WBPaper00004952 | |||||||||
WBPaper00012759 | |||||||||
WBPaper00012806 | |||||||||
WBPaper00013586 | |||||||||
WBPaper00013634 | |||||||||
Curator_confirmed | WBPerson48 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Enables several functions, including DNA-binding transcription factor activity; protein homodimerization activity; and zinc ion binding activity. Involved in several processes, including determination of adult lifespan; intracellular signal transduction; and positive regulation of transcription by RNA polymerase II. Located in germ cell nucleus; nucleolus; and nucleoplasm. Expressed in Z2; Z3; germ line; pharyngeal cell; and pharynx. Used to study cancer. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00004952 | ||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 03 Feb 2020 00:00:00 | ||||||||
Models_disease_in_annotation | WBDOannot00000735 | ||||||||
Molecular_info (7) | |||||||||
Experimental_info (11) | |||||||||
Map_info | Map | I | Position | 2.73569 | Error | 0.00602 | |||
Positive | Positive_clone | F52B5 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Mapping_data | Multi_point | 4212 | |||||||
4897 | |||||||||
Pseudo_map_position | |||||||||
Reference (251) | |||||||||
Picture | WBPicture0000013091 | ||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
[wm99ab616], [wm2001p535] and [jwm2000ab65] used cep-1 as an unapproved name for CGC plx-2 (K04B12.1). The CGC cep-1 (F52B5.5) is a p53 homolog. | |||||||||
Method | Gene |