WormBase Tree Display for Gene: WBGene00000212
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WBGene00000212 | Evidence | Paper_evidence | WBPaper00003086 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | ZK455 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | asm-2 | Person_evidence | WBPerson250 | |||||
Sequence_name | ZK455.4 | ||||||||
Molecular_name | ZK455.4 | ||||||||
ZK455.4.1 | |||||||||
CE31674 | |||||||||
Other_name | CELE_ZK455.4 | Accession_evidence | NDB | BX284606 | |||||
Public_name | asm-2 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | asm | ||||||||
Allele (50) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (28) | |||||||||
Ortholog (40) | |||||||||
Paralog | WBGene00000211 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
WBGene00000213 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00014106 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | asm-2 encodes a protein similar to human acid sphingomyelinase (ASM) or sphingomyelin phosphodiesterase 1; the ASM-2 protein has a putative secretory signal peptide at the N-terminus, saposin-like and proline-rich domains and putative N-linked glycosylation sites; asm-2 shows phosphodiesterase activity when expressed in COS-7 cells; like mammalian ASM, asm-2 is probably both intracellular and secreted; northern blot analysis indicates that asm-2 is expressed during post-embryonic development as compared to asm-1 which is expressed at higher levels in the embryo; human ASM is implicated in Niemann-Pick disease type B (OMIM:607608). | Paper_evidence | WBPaper00003086 | |||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson1823 | |||||||||
WBPerson567 | |||||||||
Date_last_updated | 09 Aug 2006 00:00:00 | ||||||||
Automated_description | Enables sphingomyelin phosphodiesterase activity. Involved in ceramide biosynthetic process and sphingomyelin catabolic process. Located in extracellular region. Human ortholog(s) of this gene implicated in Niemann-Pick disease type A and Niemann-Pick disease type B. Is an ortholog of human SMPD1 (sphingomyelin phosphodiesterase 1). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:14504 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11120) | ||||
DOID:0070112 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11120) | ||||||
DOID:0070111 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11120) | ||||||
Molecular_info | Corresponding_CDS | ZK455.4 | |||||||
Corresponding_CDS_history | ZK455.4:wp83 | ||||||||
Corresponding_transcript | ZK455.4.1 | ||||||||
Other_sequence (32) | |||||||||
Associated_feature | WBsf654409 | ||||||||
WBsf237956 | |||||||||
Experimental_info (8) | |||||||||
Map_info | Map | X | Position | 2.95988 | Error | 0.006229 | |||
Positive | Positive_clone | ZK455 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Pseudo_map_position | |||||||||
Reference (13) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |