WormBase Tree Display for Gene: WBGene00000147
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WBGene00000147 | SMap | S_parent | Sequence | VF36H2L | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | aph | ||||||
Allele (29) | |||||||
Legacy_information | [C.elegansII] zu123 : maternal effect lethal, no anterior pharynx;resembles Glp-1 embryonic phenotype but no Lag or germ line phenotypes. Maternal rescue complete.OA1: zu147 (weaker allele).[JJ] | ||||||
or28 : mutants exhibit a recessive, fully penetrant egg-laying defect; aph-1(or28) is also maternal effect Emb. | |||||||
Strain | WBStrain00004780 | ||||||
WBStrain00007372 | |||||||
WBStrain00007373 | |||||||
WBStrain00007374 | |||||||
WBStrain00007375 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (24) | |||||||
Contained_in_operon | CEOP1542 | ||||||
Ortholog (38) | |||||||
Structured_description | Concise_description | aph-1 encodes an unfamiliar protein predicted to have seven transmembrane domains; APH-1 is a component of the GLP-1/LIN-12 (Notch) pathway, is required maternally for embryonic viability, and also affects morphogenesis, egg laying, germ line proliferation, and translocation of APH-2 to the cell surface; with PEN-2, APH-1 is required for Notch pathway signaling, gamma-secretase cleavage of beta-amyloid precursor protein, and presenilin protein accumulation. | Paper_evidence | WBPaper00005082 | |||
WBPaper00005374 | |||||||
Curator_confirmed | WBPerson48 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Predicted to enable protein-macromolecule adaptor activity. Involved in several processes, including cell differentiation; pharynx development; and protein localization to cell surface. Predicted to be located in endoplasmic reticulum. Predicted to be part of gamma-secretase complex. Human ortholog(s) of this gene implicated in coronary artery disease. Is an ortholog of human APH1A (aph-1 homolog A, gamma-secretase subunit) and APH1B (aph-1 homolog B, gamma-secretase subunit). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:3393 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:24080) | ||
Molecular_info | Corresponding_CDS | VF36H2L.1 | |||||
Corresponding_transcript | VF36H2L.1.1 | ||||||
Other_sequence (18) | |||||||
Associated_feature | WBsf664684 | ||||||
WBsf664685 | |||||||
WBsf220056 | |||||||
WBsf220057 | |||||||
Experimental_info | RNAi_result (20) | ||||||
Expr_pattern | Expr1013430 | ||||||
Expr1030079 | |||||||
Expr1158014 | |||||||
Expr2009358 | |||||||
Expr2027594 | |||||||
Drives_construct | WBCnstr00007289 | ||||||
WBCnstr00037704 | |||||||
Construct_product | WBCnstr00007283 | ||||||
WBCnstr00007288 | |||||||
WBCnstr00007289 | |||||||
WBCnstr00007290 | |||||||
WBCnstr00037704 | |||||||
Microarray_results (19) | |||||||
Expression_cluster (106) | |||||||
Interaction (62) | |||||||
WBProcess | WBbiopr:00000072 | ||||||
Map_info | Map | I | Position | 3.6794 | Error | 0.007271 | |
Well_ordered | |||||||
Positive | Positive_clone | VF36H2L | Inferred_automatically (2) | ||||
Mapping_data | Multi_point | 2276 | |||||
2277 | |||||||
5072 | |||||||
Pos_neg_data | 6815 | ||||||
6816 | |||||||
Reference (34) | |||||||
Method | Gene |