WormBase Tree Display for Gene: HGNC:40
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| HGNC:40 | Identity | Name | CGC_name | ABCB1 | Inferred_automatically | AGR_import |
|---|---|---|---|---|---|---|
| Other_name (20) | ||||||
| Public_name | ABCB1 | |||||
| DB_info | Database | HGNC | id | 40 | ||
| AGR | cURI | HGNC:40 | ||||
| EnsEMBL | ENSEMBL_geneID | ENSG00000085563 | ||||
| UniProt | UniProt_AC | P08183 | ||||
| OMIM | gene | 171050 | ||||
| DO | id (32) | |||||
| Species | Homo sapiens | |||||
| Status | Live | |||||
| Gene_info | Biotype | SO:0001217 | ||||
| Ortholog (11) | ||||||
| Structured_description | Automated_description | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017] | Inferred_automatically | AGR_import |
