WormBase Tree Display for Gene: HGNC:29814
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| HGNC:29814 | Identity | Name | CGC_name | mus81 | Inferred_automatically | AGR_import |
|---|---|---|---|---|---|---|
| Other_name | RGD:1323679 | |||||
| FLJ21012 | ||||||
| FLJ44872 | ||||||
| MUS81 endonuclease homolog | ||||||
| SLX3 | ||||||
| SLX3 structure-specific endonuclease subunit homolog | ||||||
| crossover junction endonuclease MUS81 | ||||||
| mus81 endonuclease homolog (yeast) | ||||||
| Public_name | mus81 | |||||
| DB_info | Database | HGNC | id | 29814 | ||
| AGR | cURI | HGNC:29814 | ||||
| EnsEMBL | ENSEMBL_geneID | ENSG00000172732 | ||||
| UniProt | UniProt_AC | Q96NY9 | ||||
| Species | Homo sapiens | |||||
| Status | Live | |||||
| Gene_info | Biotype | SO:0001217 | ||||
| Ortholog | WBGene00016602 | Caenorhabditis elegans | From_analysis | EnsEMBL-Compara | ||
| Hieranoid | ||||||
| OrthoInspector | ||||||
| Panther | ||||||
| PhylomeDB | ||||||
| Structured_description | Automated_description | This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. [provided by RefSeq, Jun 2017] | Inferred_automatically | AGR_import |
