WormBase Tree Display for Gene: HGNC:171

HGNC:171 Identity: Name: CGC_name: Acvr1 Inferred_automatically: AGR_import
      Other_name (17)
      Public_name: Acvr1
    DB_info: Database: HGNC id 171
        AGR cURI HGNC:171
        EnsEMBL ENSEMBL_geneID ENSG00000115170
        UniProt UniProt_AC Q04771
        OMIM gene 102576
        DO id DOID:1793
            DOID:1405
            DOID:13641
            DOID:13374
            DOID:13129
            DOID:1070
    Species: Homo sapiens
    Status: Live
  Gene_info: Biotype: SO:0001217
    Ortholog: WBGene00004860 Caenorhabditis elegans From_analysis: EnsEMBL-Compara
            OrthoInspector
            SonicParanoid
      WBGene00000897 Caenorhabditis elegans From_analysis: EnsEMBL-Compara
            Inparanoid
            SonicParanoid
    Structured_description: Automated_description: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008] Inferred_automatically: AGR_import