WormBase Tree Display for Gene: HGNC:12470
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| HGNC:12470 | Identity | Name | CGC_name | Uba3 | Inferred_automatically | AGR_import |
|---|---|---|---|---|---|---|
| Other_name (16) | ||||||
| Public_name | Uba3 | |||||
| DB_info | Database | HGNC | id | 12470 | ||
| AGR | cURI | HGNC:12470 | ||||
| EnsEMBL | ENSEMBL_geneID | ENSG00000144744 | ||||
| UniProt | UniProt_AC | Q8TBC4 | ||||
| Species | Homo sapiens | |||||
| Status | Live | |||||
| Gene_info | Biotype | SO:0001217 | ||||
| Ortholog | WBGene00004341 | Caenorhabditis elegans | From_analysis | EnsEMBL-Compara | ||
| Hieranoid | ||||||
| Inparanoid | ||||||
| OMA | ||||||
| OrthoFinder | ||||||
| OrthoInspector | ||||||
| Panther | ||||||
| PhylomeDB | ||||||
| SonicParanoid | ||||||
| Structured_description | Automated_description | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | Inferred_automatically | AGR_import |
