WormBase Tree Display for Gene: HGNC:10290
expand all nodes | collapse all nodes | view schema
| HGNC:10290 | Identity | Name | CGC_name | RPA2 | Inferred_automatically | AGR_import |
|---|---|---|---|---|---|---|
| Other_name | RGD:1344829 | |||||
| REPA2 | ||||||
| RF-A protein 2 | ||||||
| RP-A p32 | ||||||
| RP-A p34 | ||||||
| RPA32 | ||||||
| replication factor A protein 2 | ||||||
| replication protein A 32 kDa subunit | ||||||
| replication protein A 34 kDa subunit | ||||||
| replication protein A2, 32kDa | ||||||
| Public_name | RPA2 | |||||
| DB_info | Database | HGNC | id | 10290 | ||
| AGR | cURI | HGNC:10290 | ||||
| EnsEMBL | ENSEMBL_geneID | ENSG00000117748 | ||||
| UniProt | UniProt_AC | P15927 | ||||
| Species | Homo sapiens | |||||
| Status | Live | |||||
| Gene_info | Biotype | SO:0001217 | ||||
| Ortholog | WBGene00019767 | Caenorhabditis elegans | From_analysis | EnsEMBL-Compara | ||
| Hieranoid | ||||||
| Inparanoid | ||||||
| OMA | ||||||
| OrthoFinder | ||||||
| OrthoInspector | ||||||
| Panther | ||||||
| PhylomeDB | ||||||
| WBGene00019079 | Caenorhabditis elegans | From_analysis | Hieranoid | |||
| Inparanoid | ||||||
| OrthoFinder | ||||||
| Panther | ||||||
| Structured_description | Automated_description | This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017] | Inferred_automatically | AGR_import |
