WormBase Tree Display for Gene: WBGene00001309
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WBGene00001309 | SMap | S_parent | Sequence | M01D7 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | emr-1 | |||||||
Sequence_name | M01D7.6 | ||||||||
Molecular_name | M01D7.6 | ||||||||
M01D7.6.1 | |||||||||
CE12270 | |||||||||
M01D7.6.2 | |||||||||
Other_name | CELE_M01D7.6 | Accession_evidence | NDB | BX284601 | |||||
Public_name | emr-1 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:24 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info (9) | |||||||||
Disease_info | Experimental_model | DOID:11726 | Homo sapiens | Paper_evidence | WBPaper00044786 | ||||
Accession_evidence | OMIM | 181350 | |||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 09 Oct 2017 00:00:00 | ||||||||
Disease_relevance | Mutations in the human ortholog of emr-1, emerin, cause X-linked Emery-Dreifuss muscular dystrophy (EDMD); Emerin is a nuclear lamina protein and belongs to a family of LEM (LAP2-Emerin-MAN1) domain proteins that include MAN1, LEM2/NET25 and several others; LEM domain proteins bind lamin; mutations in human LMNA/lamin cause several laminopathic diseases including EDMD; much of the knowledge of the organization and assembly of the nuclear lamina has come from studies in elegans; studies in elegans have demonstrated the overlapping roles of emerin and lem-2 in embryogenesis, cell proliferation, lamin and heterochromatin organization; worm emerin and lem-2 are also involved in mitosis, smooth and striated muscle function, lifespan and meiotic progression, pointing to the many underlying processes that may affect disease phenotypes. | Homo sapiens | Paper_evidence | WBPaper00040268 | |||||
Accession_evidence | OMIM | 310300 | |||||||
300384 | |||||||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 01 Mar 2012 00:00:00 | ||||||||
Models_disease_asserted | WBDOannot00000045 | ||||||||
Molecular_info | Corresponding_CDS | M01D7.6 | |||||||
Corresponding_transcript | M01D7.6.1 | ||||||||
M01D7.6.2 | |||||||||
Other_sequence | GRC02002_1 | ||||||||
GPC01900_1 | |||||||||
CRC09112_1 | |||||||||
CR02292 | |||||||||
GP02519 | |||||||||
CBC09681_1 | |||||||||
Associated_feature (3) | |||||||||
Experimental_info | RNAi_result (12) | ||||||||
Expr_pattern (13) | |||||||||
Drives_construct | WBCnstr00000686 | ||||||||
WBCnstr00000688 | |||||||||
WBCnstr00003365 | |||||||||
WBCnstr00018932 | |||||||||
WBCnstr00020603 | |||||||||
WBCnstr00020604 | |||||||||
WBCnstr00020605 | |||||||||
WBCnstr00037001 | |||||||||
Construct_product (11) | |||||||||
Regulate_expr_cluster | WBPaper00044786:emr-1(gk119)_downregulated | ||||||||
WBPaper00044786:emr-1(gk119)_upregulated | |||||||||
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated | |||||||||
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated | |||||||||
Antibody | WBAntibody00000305 | ||||||||
WBAntibody00000306 | |||||||||
WBAntibody00000307 | |||||||||
WBAntibody00000597 | |||||||||
WBAntibody00001856 | |||||||||
WBAntibody00001941 | |||||||||
Microarray_results (22) | |||||||||
Expression_cluster (149) | |||||||||
Interaction (84) | |||||||||
Map_info | Map | I | Position | -12.5332 | Error | 0.008453 | |||
Positive | Positive_clone | M01D7 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Mapping_data | Multi_point | 4286 | |||||||
4536 | |||||||||
Pseudo_map_position | |||||||||
Reference | WBPaper00004339 | ||||||||
WBPaper00005158 | |||||||||
WBPaper00005172 | |||||||||
WBPaper00005637 | |||||||||
WBPaper00005648 | |||||||||
WBPaper00005828 | |||||||||
WBPaper00017089 | |||||||||
WBPaper00018156 | |||||||||
WBPaper00024516 | |||||||||
WBPaper00024687 | |||||||||
WBPaper00025034 | |||||||||
WBPaper00026102 | |||||||||
WBPaper00026936 | |||||||||
WBPaper00027235 | |||||||||
WBPaper00027532 | |||||||||
WBPaper00030590 | |||||||||
WBPaper00035468 | |||||||||
WBPaper00037040 | |||||||||
WBPaper00038705 | |||||||||
WBPaper00039053 | |||||||||
WBPaper00040826 | |||||||||
WBPaper00041279 | |||||||||
WBPaper00042809 | |||||||||
WBPaper00043784 | |||||||||
WBPaper00044786 | |||||||||
WBPaper00045548 | |||||||||
WBPaper00046424 | |||||||||
WBPaper00048885 | |||||||||
WBPaper00051973 | |||||||||
WBPaper00052385 | |||||||||
WBPaper00059378 | |||||||||
WBPaper00060526 | |||||||||
WBPaper00061779 | |||||||||
WBPaper00062371 | |||||||||
WBPaper00064947 | |||||||||
WBPaper00065928 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |