cep-1 encodes an ortholog of the human tumor suppressor p53 (OMIM:191170, mutated in Li-Fraumeni syndrome) that promotes DNA damage-induced apoptosis and is required for normal meiotic segregation in the germ line, and affects sensitivity to hypoxia-induced lethality and longevity in response to starvation; CEP-1 is expressed ubiquitously in embryos and in the nucleoli of a subset of pharyngeal cells.
Enables several functions, including DNA-binding transcription factor activity; protein homodimerization activity; and zinc ion binding activity. Involved in several processes, including determination of adult lifespan; intracellular signal transduction; and positive regulation of transcription by RNA polymerase II. Located in germ cell nucleus; nucleolus; and nucleoplasm. Expressed in Z2; Z3; germ line; pharyngeal cell; and pharynx. Used to study cancer.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.
CGC_data_submission
[wm99ab616], [wm2001p535] and [jwm2000ab65] used cep-1 as an unapproved name for CGC plx-2 (K04B12.1). The CGC cep-1 (F52B5.5) is a p53 homolog.