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WormBase Tree Display for Gene: WBGene00000212

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Name Class

WBGene00000212EvidencePaper_evidenceWBPaper00003086
SMapS_parentSequenceZK455
Identity (6)
Gene_infoBiotypeSO:0001217
Gene_classasm
Allele (50)
RNASeq_FPKM (74)
GO_annotation (28)
Ortholog (40)
ParalogWBGene00000211Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00000213Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00014106Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionasm-2 encodes a protein similar to human acid sphingomyelinase (ASM) or sphingomyelin phosphodiesterase 1; the ASM-2 protein has a putative secretory signal peptide at the N-terminus, saposin-like and proline-rich domains and putative N-linked glycosylation sites; asm-2 shows phosphodiesterase activity when expressed in COS-7 cells; like mammalian ASM, asm-2 is probably both intracellular and secreted; northern blot analysis indicates that asm-2 is expressed during post-embryonic development as compared to asm-1 which is expressed at higher levels in the embryo; human ASM is implicated in Niemann-Pick disease type B (OMIM:607608).Paper_evidenceWBPaper00003086
Curator_confirmedWBPerson324
WBPerson1823
WBPerson567
Date_last_updated09 Aug 2006 00:00:00
Automated_descriptionEnables sphingomyelin phosphodiesterase activity. Involved in ceramide biosynthetic process and sphingomyelin catabolic process. Located in extracellular region. Human ortholog(s) of this gene implicated in Niemann-Pick disease type A and Niemann-Pick disease type B. Is an ortholog of human SMPD1 (sphingomyelin phosphodiesterase 1).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:14504Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11120)
DOID:0070112Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11120)
DOID:0070111Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11120)
Molecular_infoCorresponding_CDSZK455.4
Corresponding_CDS_historyZK455.4:wp83
Corresponding_transcriptZK455.4.1
Other_sequence (32)
Associated_featureWBsf654409
WBsf237956
Experimental_infoRNAi_resultWBRNAi00038298Inferred_automaticallyRNAi_primary
WBRNAi00059434Inferred_automaticallyRNAi_primary
WBRNAi00000331Inferred_automaticallyRNAi_primary
Expr_patternExpr1013294
Expr1162861
Expr2009455
Expr2027692
Drives_constructWBCnstr00037660
Construct_productWBCnstr00037660
AntibodyWBAntibody00001822
Microarray_results (18)
Expression_cluster (207)
InteractionWBInteraction000133965
WBInteraction000177307
WBInteraction000290792
Map_infoMapXPosition2.95988Error0.006229
PositivePositive_cloneZK455Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00003086
WBPaper00023380
WBPaper00032243
WBPaper00038491
WBPaper00042257
WBPaper00045355
WBPaper00055090
WBPaper00059755
WBPaper00062931
WBPaper00064543
WBPaper00064841
WBPaper00065215
WBPaper00065331
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene