spe-19 is predicted to encode a novel single-pass transmembrane protein with no significant similarity to any other gene product; spe-19 is required for hermaphrodite spermiogenesis or sperm activation but not for male-derived sperm activation (sperm activation is the morphogenesis of a round non-motile spermatid to an amoeboid crawling sperm); however, spe-19 mutant hermaphrodite spermatids can transactivate to form functional sperm during mating with males; spe-19 is likely to be the receptor/co-receptor for the sperm activation signal; genetic and phenotypic evidence suggests that spe-19 acts in a common pathway with spe-8, spe-12, spe-27 and spe-29.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.