dph-3 encodes a small protein conserved in diverse eukaryotes, with a CSL motif (a probable zinc finger, sometimes found associated with the N-terminal domain of DnaJ protein); DPH-3 is probably a small subunit or ancillary protein of RNA polymerase II Elongator or of a hypothetical diphthamide synthase complex; DPH-3 is orthologous to mammalian DESR1 (diphtheria toxin and Pseudomonas exotoxin A sensitivity required gene 1) and S. cerevisiae KTI11; DESR1, and probably KTI11, enables the first step in posttranslational modification of histidine to dipthamide.
Predicted to enable ferrous iron binding activity and iron chaperone activity. Predicted to be involved in protein histidyl modification to diphthamide and tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation. Located in nucleus. Is an ortholog of human DPH3 (diphthamide biosynthesis 3) and DPH3P1 (diphthamide biosynthesis 3 pseudogene 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.