pyp-1 encodes, by alternative splicing, three isoforms of an inorganic pyrophosphatase required for embryonic and larval viability, intestinal function, and distal tip cell migration; PYP-1 is catalytically active in vitro, and is expressed in neurons, intestine, and coelomocytes; PYP-1 is orthologous to Drosophila NURF-38, and to human PPA1 (OMIM:179030) and PPA2; by orthology with NURF-38, PYP-1 is also predicted to participate in nucleosome remodelling.
Predicted to enable inorganic diphosphate phosphatase activity. Involved in innate immune response. Located in neuron projection and vacuole. Expressed in coelomocyte and neurons. Is an ortholog of human PPA1 (inorganic pyrophosphatase 1) and PPA2 (inorganic pyrophosphatase 2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.