wrt-2 encodes a hedgehog-like protein, with an N-terminal signalsequence, a Wart domain, and a C-terminal region of low-complexitysequence; WRT-2 is expressed in seam cells and hypodermal syncytia; theWart domain is predicted to form a cysteine-crosslinked protein involvedin intercellular signalling, and it has subtle similarity to theN-terminal Hedge domain of HEDGEHOG proteins; WRT-2 is weakly requiredfor normal molting; WRT-2 is also required for normal growth to fullsize and locomotion; all of these requirements may reflect commondefects in cholesterol-dependent hedgehog-like signalling or in vesicletrafficking; in two-hybrid assays, WRT-2 binds EYA-1, which may parallelthe derepression of Drosophila eyes absent by HEDGEHOG.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.