eif-3.C encodes a putative c subunit of translation initiation factor 3 that is required for fertility and for embryonic osmotic integrity; eif-3.C is orthologous to human EIF3S8 (OMIM:603916) and budding yeast NIP1.
Predicted to enable translation initiation factor binding activity. Predicted to contribute to translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex. Is an ortholog of human EIF3C (eukaryotic translation initiation factor 3 subunit C) and EIF3CL (eukaryotic translation initiation factor 3 subunit C like).
The capital letters are used here to distinguish the different eIF3 subunit genes. This roughly agrees with worm gene nomenclature and it makes clear the orthologies for these universal factors (eif-3B corresponding to eIF3b, and so on), in the unified eIF3 nomenclature proposed by Browning KS et al (2001)[JAH][030106 ck1]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.