[Pettitt J, Wood WB] Encodes a cadherin-related protein. 10kb transcript detected on Northern blots, in late-stage embryo and L1 larval RNA. lac-Z driven by a 5 kb promoter fragment results in lac-Z expression in seam cells in comma-stage through to 3-fold embryos. A few other as yet unidentified hypodermal cells also stain in the anterior.
cdh-3 encodes a member of the cadherin superfamily that affects morphogenesis of tail epithelia and excretory function; expressed predominantly in developing epithelial cells, and also expressed in the AC, excretory cell, various neurons, and vulval cells during different stages of development.
Predicted to enable structural molecule activity. Involved in basement membrane disassembly and nematode male tail tip morphogenesis. Located in basement membrane; cytoplasm; and plasma membrane. Expressed in several structures, including HSN; VC neuron; anchor cell; epithelial cell; and ventral nerve cord.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.