bam-2 encodes a 1007-residue protein with a predicted N-terminal signalsequence and C-terminal transmembrane sequence, and a central concanavalinA-like lectin/glucanase motif, but no obvious homologs outside ofnematodes; BAM-2 is suggested to be related to neurexins on the basis of weaksimilarities in putatively shared sequence motifs; bam-2 mutants have VCaxon branches that overshoot their normal termination sites too farmedially into vulval epithelium, while showing no other obviousphenotypes; the bam-2 mutant phenotype is rescued by transgenic expressioneither in VulF or in all epidermal cells, even if BAM-2's cytoplasmicdomain is deleted; however, defective branching is observed if bam-2 isexpressed within VC neurons themselves; BAM-2 is thus likely to be apermissive ligand on the surface of VulF cells that attracts branchtermination but need not be restricted to VulF cells alone.
Predicted to be involved in nervous system development. Located in plasma membrane. Expressed in head neurons; somatic gonad; tail neurons; ventral cord neurons; and vulF.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.