mir-241 encodes a microRNA, a small non-protein coding RNA and appears to have a potential ortholog in C. briggsae; based on RNA sequence identity, miR-241 belongs to the let-7 family of microRNAs along with C. elegans miR-48 and miR-84 and human let-7, miR-196-1 and miR-196-2; mir-241 acts redundantly with miR-48 and mir-84 to control L2 to L3 larval and larval to adult stage transitions; miR-241 is strongly expressed from the L3 larval stage into the adult stage in normal worms and in glp-4(bn2) mutant worms.
Involved in miRNA-mediated gene silencing by inhibition of translation and positive regulation of development, heterochronic. Expressed in body wall musculature; excretory canal; hermaphrodite distal tip cell; and touch receptor neurons. Used to study Parkinson's disease.
mir-241 is a small non-protein coding RNA that belongs to the let-7 family; microRNA expression profiling studies indicate that mir-241 is overexpressed in an elegans Parkinson''s disease model, the pdr-1 mutant (pdr-1 is orthologous to human PARKIN).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.