WormBase Tree Display for Gene: WBGene00001749

WBGene00001749 Evidence: Person_evidence: WBPerson1846
  SMap: S_parent: Sequence: R107
  Identity: Version: 1
    Name (5)
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gst
    Allele (13)
    Legacy_information: [C.elegansII] NMK. Encodes predicted glutathione-S-transferase P subunit. Transpliced to SL2. [Weston et al. 1989]
    RNASeq_FPKM (74)
    GO_annotation (18)
    Contained_in_operon: CEOP3572
    Ortholog (31)
    Paralog (45)
    Structured_description: Concise_description: gst-1 encodes a putative glutathione S-transferase of the pi class;GST-1 is required for sperm to normally migrate towards a PUFA-basedsignal exuded by oocytes; gst-1(RNAi) hermaphrodites are infertile,both through aberrant loss of their own sperm and through failure ofmales to effectively inseminate them. Paper_evidence: WBPaper00028527
          Curator_confirmed: WBPerson48
            WBPerson567
          Date_last_updated: 12 Mar 2007 00:00:00
      Automated_description: Enables glutathione transferase activity. Involved in cellular detoxification; defense response to other organism; and regulation of cellular response to manganese ion. Predicted to be located in cytosol. Expressed in DA neuron. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autoimmune disease (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of human GSTP1 (glutathione S-transferase pi 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050745 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:2841 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:1584 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:8997 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:615 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:1037 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:1070 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:0050902 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:0050908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:0080750 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:8283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:11088 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:9471 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:3132 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:1579 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:8692 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:0060500 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:0050861 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:8618 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:10241 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:1324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:8568 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:5419 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:418 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:4029 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:3407 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:10320 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:1210 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:8923 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:0050589 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:4450 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:1793 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:13550 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:11650 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:9119 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:1555 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:9538 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:4467 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:0050866 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:9351 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:9669 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:11934 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:13223 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4637)
      DOID:2394 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:9655 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:8567 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:2596 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:0050567 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:824 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:3904 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:7148 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:299 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:4906 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:10892 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:11166 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:0080177 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:409 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:9952 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:2957 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:5041 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:11054 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:13641 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:1909 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:3021 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:3070 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:5082 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:1749 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:3883 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:8778 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:0060892 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:74 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:8893 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:10159 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:12449 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:3770 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:4362 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:0060071 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:850 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:10873 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:8577 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:4448 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:10487 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:0002116 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:9074 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:161 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:3083 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:4250 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:10591 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:5773 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:1682 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:13636 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:4947 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:1485 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:10485 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:574 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:2377 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:3069 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:0080199 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:12361 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:4926 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:3121 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:3602 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:9744 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:0050860 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:4961 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:83 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:3748 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:2671 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:14330 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:1205 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:8947 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:9261 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:3587 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:4914 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:3310 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:1474 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:14067 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:11476 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:480 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:12849 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:0050426 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:2152 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:1790 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:2998 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4638)
      DOID:2893 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:0081267 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:783 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
      DOID:9675 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632,HGNC:4638)
      DOID:3393 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4632)
  Molecular_info: Corresponding_CDS: R107.7
    Corresponding_transcript: R107.7.1
    Other_sequence (57)
    Associated_feature: WBsf645457
      WBsf645458
      WBsf645459
      WBsf981541
      WBsf993558
      WBsf225512
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr11048
      Expr1018206
      Expr1031042
      Expr1155346
      Expr2012303
      Expr2030539
    Drives_construct: WBCnstr00019132
      WBCnstr00036720
    Construct_product: WBCnstr00036720
    Antibody: WBAntibody00002442
    Microarray_results (22)
    Expression_cluster (205)
    Interaction (46)
  Map_info: Map: III Position: 0.129472 Error: 0.002939
    Positive: Positive_clone: R107 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (23)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene