WormBase Tree Display for Gene: WBGene00010369

WBGene00010369 SMap: S_parent: Sequence: H06O01
  Identity: Version: 2
    Name: CGC_name: chd-1 Person_evidence: WBPerson260
      Sequence_name: H06O01.2
      Molecular_name: H06O01.2
        H06O01.2.1
        CE32454
      Other_name: CELE_H06O01.2 Accession_evidence: NDB BX284601
      Public_name: chd-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change (2)
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: chd
    Allele (91)
    Strain: WBStrain00033287
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (42)
    Paralog (19)
    Structured_description: Concise_description: H06O01.2 encodes a large (1,461-aa) putative chromodomain helicaseDNA-binding protein that inhibits DHC-1 in vivo; H06O01.2 is orthologousto budding yeast CHD1, human CHD1 (OMIM:602118), and human CHD2(OMIM:602119); H06O01.2(RNAi) suppresses the lethality of conditional dhc-1 mutations, as well as the spindle length and cytokinesis defectsof dhc-1(or195), indicating that H06O01.2 negatively regulates dynein;H06O01.2 has no obvious function in mass RNAi assays. Paper_evidence: WBPaper00030897
            WBPaper00030910
            WBPaper00030913
            WBPaper00030915
          Curator_confirmed: WBPerson567
          Date_last_updated: 26 Aug 2007 00:00:00
      Automated_description: Predicted to enable several functions, including ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; and chromatin binding activity. Predicted to be involved in nucleosome organization and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. Expressed in several structures, including germ cell and somatic cell. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma and developmental and epileptic encephalopathy 94. Is an ortholog of human CHD1 (chromodomain helicase DNA binding protein 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080909 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1915)
      DOID:10283 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1915)
      DOID:0081325 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1917)
  Molecular_info: Corresponding_CDS: H06O01.2
    Corresponding_CDS_history: H06O01.2:wp90
    Corresponding_transcript: H06O01.2.1
    Other_sequence: HG00341
      EY469363.1
      MH10166
      HG00417
      JI164161.1
      JI172399.1
      FG980728.1
      FG975475.1
      Acan_isotig05916
      FG974365.1
      BMC07689_1
      FG978579.1
      EY470985.1
      Name_isotig01465
      Acan_isotig09352
      GRC04416_1
      OVC09204_1
      GP00193
      EL888073.1
      FG975258.1
      HBC05698_1
      SS03116
      Oden_isotig19740
      ASC07038_1
      Hbac_isotig01126
      HBC00057_1
      XI04228
      AS05591
      Acan_isotig05917
      EY470341.1
      EX552963.1
      JI164141.1
      MH10167
      Hbac_isotig01591
      EY460171.1
      FG978685.1
      BG310503.1
      TDC02778_1
      GPC01497_1
      MH02674
      FK800973.1
      PVC02882_1
      FG980905.1
      CBC17213_1
      FC552108.1
      Oden_isotig19172
      FG973165.1
      ACC09017_1
      EX549111.1
      AE03059
      HGC11397_1
      ACC09786_1
      AM743780.1
      JI481538.1
      EY470632.1
      ACC04591_1
      EX559429.1
      OFC00224_1
      HSC00152_1
      AYC01516_1
      Tcir_isotig06585
      JO468865.1
      MHC07741_1
      OF01335
      Dviv_isotig26371
      Acan_isotig20741
      EX916638.1
      MH10174
      JI170488.1
      HGC03991_1
      Acan_isotig21323
      FC549167.1
      XIC04631_1
      HS00080
      JI476138.1
      JO470250.1
      Dviv_isotig23610
      FK801333.1
      EW741676.1
      GR17294
      ACC01560_1
      FG974377.1
      Tcol_isotig16582
      FK806016.1
    Associated_feature: WBsf664384
      WBsf664385
      WBsf664386
      WBsf984049
      WBsf1010014
      WBsf219666
  Experimental_info: RNAi_result: WBRNAi00116963 Inferred_automatically: RNAi_primary
      WBRNAi00003875 Inferred_automatically: RNAi_primary
      WBRNAi00001022 Inferred_automatically: RNAi_primary
      WBRNAi00081577 Inferred_automatically: RNAi_primary
      WBRNAi00113475 Inferred_automatically: RNAi_primary
      WBRNAi00075562 Inferred_automatically: RNAi_primary
      WBRNAi00049332 Inferred_automatically: RNAi_primary
      WBRNAi00003874 Inferred_automatically: RNAi_primary
      WBRNAi00116962 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr16307
      Expr16308
      Expr1018394
      Expr1034528
      Expr1153070
      Expr2009955
      Expr2028195
    Drives_construct: WBCnstr00031462
    Construct_product: WBCnstr00031462
    Microarray_results (18)
    Expression_cluster (109)
    Interaction (71)
  Map_info: Map: I Position: 1.63154 Error: 0.008067
    Positive: Positive_clone: H06O01 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00015650
    WBPaper00038491
    WBPaper00047313
    WBPaper00055090
    WBPaper00062707
    WBPaper00063052
    WBPaper00065308
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene