WormBase Tree Display for Gene: WBGene00004063
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| WBGene00004063 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pmr-1 | |||||||
| Sequence_name | ZK256.1 | ||||||||
| Molecular_name (11) | |||||||||
| Other_name | pmr1 | Accession_evidence | EMBL | AJ303081 | |||||
| AJ303082 | |||||||||
| CELE_ZK256.1 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | pmr-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pmr | ||||||||
| Allele (285) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (35) | |||||||||
| Contained_in_operon | CEOP1682 | ||||||||
| Ortholog (42) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | The pmr-1 gene encodes a Golgi P-type ATPase Ca^2+/Mn^2+-pump; mutations in its human ortholog, ATP2C1, cause Hailey-Hailey disease (OMIM:169600). | Paper_evidence | WBPaper00004659 | |||||
| Curator_confirmed | WBPerson1823 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables P-type calcium transporter activity and P-type manganese transporter activity. Involved in several processes, including metal ion transport; response to metal ion; and response to oxidative stress. Located in Golgi apparatus and membrane. Expressed in male gonad; seam cell; and spermatheca. Human ortholog(s) of this gene implicated in Hailey-Hailey disease. Is an ortholog of human ATP2C1 (ATPase secretory pathway Ca2+ transporting 1) and ATP2C2 (ATPase secretory pathway Ca2+ transporting 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0050429 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13211) | ||||
| Disease_relevance | C. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, a small heat shock protein (sHSP), HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpression of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes. | Homo sapiens | Paper_evidence | WBPaper00041564 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 29 May 2013 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | ZK256.1a | |||||||
| ZK256.1b | |||||||||
| ZK256.1c | |||||||||
| Corresponding_CDS_history | ZK256.1:wp114 | ||||||||
| ZK256.1a:wp49 | |||||||||
| ZK256.1b:wp77 | |||||||||
| Corresponding_transcript | ZK256.1a.1 | ||||||||
| ZK256.1a.2 | |||||||||
| ZK256.1a.3 | |||||||||
| ZK256.1b.1 | |||||||||
| ZK256.1c.1 | |||||||||
| Other_sequence | AJ303081 | ||||||||
| AJ303082 | |||||||||
| CN477593.1 | |||||||||
| Acan_isotig13623 | |||||||||
| Dviv_isotig24902 | |||||||||
| EX543455.1 | |||||||||
| EX566432.1 | |||||||||
| CR12174 | |||||||||
| EY470107.1 | |||||||||
| ALC00148_1 | |||||||||
| FC550172.1 | |||||||||
| EY466314.1 | |||||||||
| EY463640.1 | |||||||||
| JI165905.1 | |||||||||
| HBC01340_1 | |||||||||
| JI165057.1 | |||||||||
| TSC07074_1 | |||||||||
| RSC01148_1 | |||||||||
| Acan_isotig07568 | |||||||||
| JI478504.1 | |||||||||
| FG621044.1 | |||||||||
| CJC11851_1 | |||||||||
| MA02337 | |||||||||
| FG972967.1 | |||||||||
| BU586242.1 | |||||||||
| Name_isotig01837 | |||||||||
| MP01829 | |||||||||
| PPC14896_1 | |||||||||
| FG621051.1 | |||||||||
| JI472315.1 | |||||||||
| EX546583.1 | |||||||||
| FG971662.1 | |||||||||
| XIC05022_1 | |||||||||
| EX538332.1 | |||||||||
| MPC00699_1 | |||||||||
| RS07775 | |||||||||
| ES566197.1 | |||||||||
| RS09496 | |||||||||
| CV199735.1 | |||||||||
| MHC01968_1 | |||||||||
| EX537879.1 | |||||||||
| DN152885.1 | |||||||||
| FG621050.1 | |||||||||
| Hbac_isotig01739 | |||||||||
| EX552731.1 | |||||||||
| AI539869.1 | |||||||||
| JI482680.1 | |||||||||
| HGC12012_1 | |||||||||
| Tcol_isotig19616 | |||||||||
| EX564614.1 | |||||||||
| MJ04725 | |||||||||
| FC539231.1 | |||||||||
| DI01694 | |||||||||
| SS00050 | |||||||||
| Tcol_isotig08685 | |||||||||
| MC02343 | |||||||||
| JI462149.1 | |||||||||
| OVC02782_1 | |||||||||
| Tcol_isotig08686 | |||||||||
| Tcir_isotig15669 | |||||||||
| CRC06593_1 | |||||||||
| HG05087 | |||||||||
| XI04504 | |||||||||
| HBC00938_1 | |||||||||
| PT01978 | |||||||||
| FG621045.1 | |||||||||
| HBC15419_1 | |||||||||
| Hbac_isotig05535 | |||||||||
| MH04508 | |||||||||
| JI474100.1 | |||||||||
| Oden_isotig14510 | |||||||||
| FC555077.1 | |||||||||
| EY461332.1 | |||||||||
| JI466111.1 | |||||||||
| ACC07220_1 | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info (8) | |||||||||
| Map_info | Map | I | Position | 17.0977 | Error | 0.064933 | |||
| Positive | Positive_clone | ZK256 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 5071 | |||||||
| Pseudo_map_position | |||||||||
| Reference (22) | |||||||||
| Remark | Sequence connection from [Van Baelenk, Wuytack, F] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
