WormBase Tree Display for Gene: WBGene00000776

WBGene00000776 Evidence: Paper_evidence: WBPaper00004821
  SMap: S_parent: Sequence: T03E6
  Identity: Version: 1
    Name: CGC_name: cpl-1
      Sequence_name: T03E6.7
      Molecular_name: T03E6.7a
        T03E6.7a.1
        CE16333
        T03E6.7b
        CE47424
        T03E6.7b.1
      Other_name: CELE_T03E6.7 Accession_evidence: NDB BX284605
      Public_name: cpl-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cpl
    Allele (188)
    Strain: WBStrain00035678
    RNASeq_FPKM (74)
    GO_annotation (34)
    Ortholog (69)
    Paralog (28)
    Structured_description: Concise_description: cpl-1 encodes a member of the cathepsin L-like cysteine protease family required for embryonic viability and normal growth; expressed in eggshells and throughout early embryos, accumulates in intestinal cells during late embryogenesis, and expressed in the cuticle, gonad, and pharynx later in development. Paper_evidence: WBPaper00005099
            WBPaper00005654
            WBPaper00011657
            WBPaper00023209
          Curator_confirmed: WBPerson48
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable cysteine-type endopeptidase activity. Involved in several processes, including lipid droplet disassembly; positive regulation of vitellogenesis; and regulation of apoptosis involved in tissue homeostasis. Located in several cellular components, including lysosome; vesicle lumen; and yolk granule. Expressed in several structures, including cuticle; eggshell; hermaphrodite gonad; pharynx; and vulva. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy and type 2 diabetes mellitus. Is an ortholog of human CTSL (cathepsin L). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:11984 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2537)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2537)
  Molecular_info: Corresponding_CDS: T03E6.7a
      T03E6.7b
    Corresponding_transcript: T03E6.7a.1
      T03E6.7b.1
    Other_sequence: ALC00734_1
      XI04637
      EU659123.1
      FC816003.1
      Oden_isotig00407
      HGC00141_1
      BXC05077_1
      MC05885
      JO471905.1
      SR04618
      AYC03102_1
      TSC03038_2
      EX547274.1
      DA03513
      DA03582
      GR19896
      AJ557572.1
      HGC01066_1
      BU088702.1
      GR18821
      Y09498.1
      PPC00029_1
      Tcir_isotig10108
      FC545518.1
      HG02906
      PPC03168_1
      EX545740.1
      EX543255.1
      TLC00115_1
      FC544259.1
      EX542339.1
      TS00372
      Oden_isotig00402
      EU327528.1
      ASC02160_1
      GPC00734_1
      Tcol_isotig11974
      FF680447.1
      CK855143.1
      JI171262.1
      GR19895
      RS06394
      GR977296.1
      AYC01514_1
      GR11432
      PSC00536
      FC810576.1
      EX912884.1
      DA02225
      EV852048.1
      CK855044.1
      EY467476.1
      TV01057
      CK726366.1
      GO252861.1
      BXC00064_1
      GPC03326_1
      HCC00501_1
      CK854789.1
      ACC00238_1
      EX916151.1
      Hbac_isotig00133
      CGC00266_1
      PPC00911_1
      FC811083.1
      XIC02144_1
      FG973733.1
      BUC00464_1
      GW407627.1
      XIC03906_1
      ES562654.1
      ACC14870_1
      FK670238.1
      FC816556.1
      AE03886
      MCC06050_1
      FC815067.1
      AY554271.1
      FD517577.1
      Tcir_isotig22496
      FE916560.1
      ES880187.1
      CK854822.1
      MH01312
      HC04498
      EX539252.1
      Acan_isotig05979
      JK315179.1
      RSC04076_1
      GR18364
      CSC00339_1
      EF413921.1
      ES565698.1
      GO251717.1
      AY999066.1
      GP02226
      FC541928.1
      TVC00499_1
      AY039743.1
      SSC00859_1
      AE00269
      HG03285
      AS05133
      FG619908.1
      DA00463
      AY999065.1
      ES568801.1
      WBC02103_1
      NAC01970_1
      ES672795.1
      GW408879.1
      BMC06080_1
      Oden_isotig00401
      HCC09806_1
      EX548240.1
      DAC01726_1
      EX544588.1
      Name_isotig01416
      PP00633
      Tcir_isotig08711
      HC01624
      Tcol_isotig11973
      EX548039.1
      EY467526.1
      DVC02618_1
      EX913611.1
      GRC04809_1
      FC819806.1
      FE920315.1
      MH10554
      ES743745.1
      EY467135.1
      RS06282
      EY470495.1
      EL890644.1
      AYC01514_2
      FC811979.1
      CJC00465_1
      MIC00733_2
      MPC00207_1
      MA01965
      GO250684.1
      ES740412.1
      FC815188.1
      MJ04825
      FD517136.1
      AS02133
      EX914313.1
      GR17142
      ES413558.1
      FC809738.1
      HGC11506_1
      GW409834.1
      EY472505.1
      EW744283.1
      EU000411.1
      FC549525.1
      SS00573
      Hbac_isotig00134
      EY465035.1
      EX534721.1
      ACC04593_1
      HG03417
      CBC00472_1
      EY473660.1
      Y09499.1
      Acan_isotig05978
      JK315978.1
      XI00736
      CGC00293_1
      FE916423.1
      BMC06248_1
      MH02371
      BU087913.1
      WBC01524_1
      NBC00664_1
      GRC00749_1
      CB037391.1
      OCC00046_1
      BU586583.1
      DAC02166_1
      EY459890.1
      EW743035.1
      MHC06575_1
      FE916231.1
      OOC02098_1
      FG976127.1
      GR17708
      FC813888.1
      ACC14667_1
      XI00692
      EX537077.1
      GP00424
      RS07901
      ACC07278_1
      FD517554.1
      JI169709.1
      Hbac_isotig00135
      SRC00465_1
      EX007611.1
      EU659125.1
      FC817020.1
      EX914657.1
      CK854610.1
      BMC05457_1
      EX548279.1
      EY471984.1
      GRC05919_1
      AY999067.1
      DA00811
      ES739341.1
      HGC11052_1
      EX828519.1
      MIC00733_1
      GR11856
      MHC12044_1
      EY459682.1
      JI169245.1
      RSC02140_1
      DAC00405_1
      PVC02808_1
      ES412728.1
      GW411559.1
      RS09720
      AI363560.1
      CK850440.1
      MHC08203_1
      HG00441
      TDC01485_1
      FK801390.1
      HGC00195_1
      DA02224
      EY469646.1
      BXC06395_1
      MAC01286_1
      FC549460.1
      MP00197
      ES740041.1
      EX536798.1
      AS00995
      MHC12231_1
      Dviv_isotig34414
      FF680156.1
      JK315088.1
      CJC03070_1
      Tcol_isotig10677
      FE920219.1
      HGC11963_1
      MI02535
      MJC03957_1
      EY470879.1
      GRC03786_1
      MIC08225_1
      CB036225.1
      HG04838
      XI04593
      EX535300.1
      XI00471
      Oden_isotig00406
      AF320084.1
      EY461223.1
      WBC01409_1
      EX535732.1
      EY464601.1
      SC00304
      BUC00818_1
      EX013120.1
      FG619907.1
      GR18365
      DA00165
      FG619909.1
      EY471480.1
      S83552.1
      EX916452.1
      HBC00991_1
      BM01244
      AE01265
      FE915949.1
      NB08235
      AYC02131_1
      FD514977.1
      HBC00976_1
      MI00900
      Hbac_isotig00132
      AE00443
      PPC04413_1
      GQ180107.1
    Associated_feature (13)
  Experimental_info: RNAi_result (20)
    Expr_pattern (17)
    Drives_construct (5)
    Construct_product: WBCnstr00010434
      WBCnstr00015512
      WBCnstr00016652
      WBCnstr00018463
      WBCnstr00018464
      WBCnstr00019401
      WBCnstr00037285
    Regulate_expr_cluster: WBPaper00064728:cpl-1(W32AY35A)_upregulated
    Antibody: WBAntibody00000451
      WBAntibody00000800
      WBAntibody00000801
      WBAntibody00000802
      WBAntibody00000803
      WBAntibody00002885
      WBAntibody00002910
    Microarray_results (23)
    Expression_cluster (236)
    Interaction (107)
  Map_info: Map: V Position: 10.72
    Positive: Positive_clone: T03E6 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4236
    Pseudo_map_position
  Reference (37)
  Remark: Sequence connection from [Hashmi S, Britton C, Lustigman S], 02/06/13 krb.
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    [200225 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (10.5333)
  Method: Gene