WormBase Tree Display for Gene: WBGene00000182

WBGene00000182 SMap: S_parent: Sequence: B0336
  Identity: Version: 3
    Name: CGC_name: arf-1
      Sequence_name: B0336.2
      Molecular_name: B0336.2
        B0336.2.1
        CE00696
        B0336.2.2
      Other_name: ARF/1
        arf-1.2
        CELE_B0336.2 Accession_evidence: NDB BX284603
      Public_name: arf-1
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 05 Nov 2004 15:32:14 WBPerson2970 Name_change: CGC_name: arf-1.2
        3 10 Sep 2020 13:24:17 WBPerson1983 Name_change: CGC_name: arf-1
                Other_name: arf-1.2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: arf
    Allele (33)
    Legacy_information: [C.elegansII] NMK. Encodes 181 aa predicted class I ARF. [CGC, MQ]
    RNASeq_FPKM (74)
    GO_annotation (22)
    Contained_in_operon: CEOP3332
    Ortholog (45)
    Paralog (14)
    Structured_description: Concise_description: arf-1.2 encodes an ADP-ribosylation factor homolog required in vivo for embryonic development, fertility, locomotion, vulval development, and cuticular synthesis; ARF proteins are N-myristoylated GTPases that regulate membrane traffic and the actin cytoskeleton, and that activate both phospholipase D1 (PLD1) and phosphatidylinositol 4-phosphate 5-kinase. Paper_evidence: WBPaper00012958
            WBPaper00013160
            WBPaper00015195
          Curator_confirmed: WBPerson567
          Date_last_updated: 16 Jul 2007 00:00:00
      Automated_description: Predicted to enable GTP binding activity and GTPase activity. Involved in several processes, including oocyte development; regulation of apoptotic process involved in development; and regulation of receptor-mediated endocytosis. Located in endoplasmic reticulum. Expressed in pharyngeal muscle cell; uterus; ventral nerve cord; and vulval precursor cell. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Is an ortholog of human ARF1 (ADP ribosylation factor 1) and ARF3 (ADP ribosylation factor 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0050454 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:652)
  Molecular_info: Corresponding_CDS: B0336.2
    Corresponding_transcript: B0336.2.1
      B0336.2.2
    Other_sequence: EX557454.1
      Oden_isotig05275
      Acan_isotig23091
      MI01929
      FC812745.1
      TSC01779_1
      ES564299.1
      NB07313
      ES408879.1
      NAC01288_1
      HGC09514_1
      AYC01793_1
      GRC00264_1
      XIC01333_1
      Acan_isotig06618
      ES408493.1
      HG01417
      EX012230.1
      EX012491.1
      MJ00146
      ES566940.1
      FG581626.1
      TSC01714_1
      RS06243
      MI09150
      HCC00675_1
      Oden_isotig17395
      RSC01890_1
      Acan_isotig11282
      EY459437.1
      PSC03851_1
      BG310560.1
      PPC00374_1
      SSC02450_1
      EX007806.1
      AS15351
      Tcir_isotig03018
      GW412187.1
      EX501365.1
      PSC01642_1
      GP02983
      RSC02072_1
      Acan_isotig13178
      HG03366
      GW411697.1
      XI00830
      HC00346
      GW406898.1
      EX014716.1
      NB06537
      AAC00735_1
      ES564292.1
      GW407273.1
      MIC07030_1
      ES562880.1
      BG734488.1
      GPC01551_1
      Tcir_isotig32322
      CJC02579_1
      BU586682.1
      GRC00446_1
      FG587808.1
      TMC02365_1
      Oden_isotig05274
      FC820205.1
      ES561326.1
      Tcir_isotig29054
      GR11812
      FG581308.1
      GW411926.1
      MI00898
      MHC06734_1
      XI05407
      GP00118
      XI01106
      DN191024.1
      GR17435
      Oden_isotig05272
      GW406409.1
      CR02217
      GW411563.1
      Oden_isotig05278
      HBC00567_1
      EX009789.1
      ES740597.1
      EX551783.1
      EE724170.1
      EX502545.1
      MJC00261_1
      CBC10134_1
      HG11251
      ES570304.1
      FC547296.1
      MJC02984_1
      SS01290
      EX913071.1
      Acan_isotig03301
      GPC02041_1
      GP02643
      NBC00202_1
      SSC02469_1
      ES412020.1
      ALC00803_1
      CBC04664_1
      Oden_isotig05277
      PPC04788_1
      EX500770.1
      JI171730.1
      Tcol_isotig09642
      MH09460
      FC818412.1
      BXC01608_1
      GW412037.1
      Dviv_isotig24100
      XIC01333_2
      GRC00306_1
      EX010565.1
      Name_isotig01278
      FC816501.1
      Oden_isotig17394
      SRC00935_1
      TSC11309_1
      GR13691
      AYC01028_1
      DA04877
      DAC02374_1
      AW506062.1
      EX008990.1
      HGC00145_1
      RS06227
      ES562646.1
      HGC00866_1
      CRC00332_1
      Hbac_isotig02224
      XIC00088_1
      EX542941.1
      GW411661.1
      Tcol_isotig22540
      Acan_isotig03300
      PP01101
      XI05236
      FK805523.1
      XI03646
      Oden_isotig05279
      FG581582.1
      GP02541
      HC00413
      EX013077.1
      TV01621
      ES569611.1
      TM00324
      SR00756
      PSC00271
      GW413112.1
      ACC00658_1
      Tcir_isotig07399
      MI08431
      AE02856
      PTC00419_1
      Tcir_isotig03019
      OVC09244_1
      EE724169.1
      TS01114
      MIC00764_1
      AS15372
      PT01102
      GR17795
      Tcol_isotig06533
      EX502420.1
      AS13932
      FC811027.1
      EX009084.1
      ES411080.1
      FG585631.1
      GO250823.1
      ES272862.1
      MI02414
      PP00330
    Associated_feature (13)
  Experimental_info: RNAi_result (38)
    Expr_pattern: Chronogram1686
      Expr3149
      Expr4834
      Expr5055
      Expr15679
      Expr1028066
      Expr1030106
      Expr1143124
      Expr2009391
      Expr2027627
    Drives_construct: WBCnstr00002999
      WBCnstr00011177
      WBCnstr00012265
      WBCnstr00019869
      WBCnstr00037680
      WBCnstr00042476
    Construct_product: WBCnstr00008785
      WBCnstr00008786
      WBCnstr00019869
      WBCnstr00037680
      WBCnstr00042476
    Microarray_results (26)
    Expression_cluster (132)
    Interaction (182)
  Map_info: Map: III Position: -1.44726 Error: 0.000356
    Positive: Positive_clone: B0336 Inferred_automatically: From sequence, transcript, pseudogene data
        NM#G4
    Mapping_data: Multi_point: 4788
        5049
    Pseudo_map_position
  Reference: WBPaper00003831
    WBPaper00004211
    WBPaper00004403
    WBPaper00006425
    WBPaper00015195
    WBPaper00024200
    WBPaper00025163
    WBPaper00027296
    WBPaper00027612
    WBPaper00028050
    WBPaper00030963
    WBPaper00031019
    WBPaper00031224
    WBPaper00032446
    WBPaper00033606
    WBPaper00038432
    WBPaper00038491
    WBPaper00040857
    WBPaper00041831
    WBPaper00045696
    WBPaper00045882
    WBPaper00047716
    WBPaper00047992
    WBPaper00048305
    WBPaper00048321
    WBPaper00049828
    WBPaper00050606
    WBPaper00052225
    WBPaper00054370
    WBPaper00055090
    WBPaper00061547
    WBPaper00061805
    WBPaper00062255
    WBPaper00062289
    WBPaper00063177
    WBPaper00064057
    WBPaper00066233
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
    This gene was previously assigned the CGC name arf-1. It has been re-assigned to arf-1.2 Curator_confirmed: WBPerson2970
  Method: Gene