fcd-2 encodes an ortholog of the human gene FANCD2 (mutated in Fanconianemia, OMIM:227646) that is strongly required for resistance to DNAinterstrand crosslinking (ICL) agents, but not to ionizing radiation (IR);fcd-2 mutants are viable and dispensable for resistance to IR, meioticrecombination, and S-phase checkpoint activation, but are hypersensitiveto ICL agents; like its human ortholog, FCD-2 is monoubiquitylated andrecruited to chromosomal foci after ICL but not IR; transgenic expresssionof the FANCD2 gene in mutant FA-D2 cells rescues their abnormalsensitivity to mitomycin C, an agent that cross-links strands of DNA.
Predicted to enable DNA polymerase binding activity. Involved in nucleotide-excision repair and regulation of DNA-templated DNA replication. Located in nucleus. Expressed in germ line. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group D2; breast cancer; and skin melanoma. Is an ortholog of human FANCD2 (FA complementation group D2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.