Predicted to enable DNA replication origin binding activity; chromatin binding activity; and single-stranded DNA binding activity. Predicted to be involved in DNA replication initiation; double-strand break repair via break-induced replication; and mitotic DNA replication preinitiation complex assembly. Located in nucleus. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Is an ortholog of human CDC45 (cell division cycle 45).
Inferred by orthology to human genes with DO annotation (HGNC:1739)
Disease_relevance
22q11.2 deletion syndrome (22q11.2DS) is the most common human deletion syndrome caused by deletion of a small piece of chromosome 22, characterized by neurodevelopmental defects, schizophrenia, congenital cardiac and craniofacial abnormalites (includes DiGeorge Syndrome and velocardiofacial syndrome); the 22q11.2 deletion overlaps several protein-coding genes including CDC45; C. elegans CDC45/evl-18 is involved in DNA replication initiation as RNAi depletion of evl-18 affects DNA replication and delays S phase; evl-18 knock-down phenotypes include reduced brood size, early embryo sister chromatid segregration defects, and sperm development and sterility defects; evl-18 provides a potential model system to study genes involved in 22q11.2DS.