WormBase Tree Display for Gene: WBGene00006917

WBGene00006917 SMap: S_parent: Sequence: C17H12
  Identity: Version: 1
    Name: CGC_name: vha-8
      Sequence_name: C17H12.14
      Molecular_name: C17H12.14
        C17H12.14.1
        CE19362
      Other_name: pes-6 CGC_data_submission
        CELE_C17H12.14 Accession_evidence: NDB BX284604
      Public_name: vha-8
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: vha
    Allele (16)
    Legacy_information: [C.elegansII] NMK. pes-6:lacZ expressed throughout H-shaped excretory cell, also in nuclei of lateral hypodermis. Clone UL#64A1, YAC 55E1. [Young and Hope 1993; UL]
    Strain: WBStrain00029316
      WBStrain00029318
      WBStrain00035242
      WBStrain00023532
      WBStrain00051766
      WBStrain00051767
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog: WBGene00027832 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00074113 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            WormBase-Compara
      WBGene00151986 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00134875 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00067080 Caenorhabditis remanei From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00114789 Pristionchus pacificus From_analysis: Inparanoid_8
      WBGene00234147 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g8054 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g11024 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g7505 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g11404 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP28.g3161 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP28.g9192 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g11556 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g9583 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g3896 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g8312 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g24101 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g6467 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g4156 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00836.g14491 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-vha-8 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g17791 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01653.g22314 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_06625 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_013754 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g10418 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g21840 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_40174200 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIV_pilon.g10687 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00243332 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00304643 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00262512 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00268005 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00302636 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000005859 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      FB:FBgn0283535 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-020419-11 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-041212-51 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:857 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:18125 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:894326 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1922165 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:735157 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1311680 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Structured_description: Concise_description: vha-8 encodes an ortholog of subunit E of the cytoplasmic (V1) domain ofvacuolar proton-translocating ATPase (V-ATPase); VHA-8 is a predictedcytosolic stator (stalk) component; VHA-8 is required for embryonic andlarval viability, for ovulation, and for receptor-mediated endocytosisof yolk protein; VHA-8 is highly expressed in the cytoplasm of excretorycanals throughout development, and in the stacked apical plasma membranesheets of syncytial hypodermal cells; general levels of VHA-8 proteinare very low in embryos but increase strongly after hatching; vha-8mutants show necrotic cell death in hypodermis and intestine,paralleling the role of VHA-12 and other V-ATPase subunits in neuronalnecrosis; VHA-8 is dispensable for alae formation, like the V1 subunitVHA-13, but not like the V0 subunits VHA-1 and VHA-4. Paper_evidence: WBPaper00006007
            WBPaper00026640
            WBPaper00027625
            WBPaper00027697
            WBPaper00028360
            WBPaper00028773
            WBPaper00028774
            WBPaper00028775
          Curator_confirmed: WBPerson48
            WBPerson567
          Date_last_updated: 19 Nov 2006 00:00:00
      Automated_description: Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Located in apical plasma membrane and cytoplasm. Expressed in head; hypodermis; and intestine. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIC. Is an ortholog of human ATP6V1E2 (ATPase H+ transporting V1 subunit E2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070140 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:857)
  Molecular_info (4)
  Experimental_info: RNAi_result (35)
    Expr_pattern (13)
    Drives_construct: WBCnstr00000144
      WBCnstr00002097
      WBCnstr00004220
      WBCnstr00010876
      WBCnstr00011962
      WBCnstr00038089
    Construct_product: WBCnstr00011962
    Antibody: WBAntibody00000656
      WBAntibody00001091
    Microarray_results (17)
    Expression_cluster (146)
    Interaction (111)
  Map_info: Map: IV Position: 3.23455 Error: 0.001195
    Positive: Positive_clone: C17H12 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4752
        5424
    Pseudo_map_position
  Reference (25)
  Remark: pes-6 was incorrectly connected to C17H12.4 [030416 ck1]
    The pes-6 was merged with vha-8 following advice from the CGC. pes-6 is now an other name of vha-8 [krb 030512]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene