WormBase Tree Display for Gene: WBGene00006452

WBGene00006452 SMap: S_parent: Sequence: R148
  Identity: Version: 1
    Name: CGC_name: heh-1 Person_evidence: WBPerson655
      Sequence_name: R148.6
      Molecular_name: R148.6
        R148.6.1
        CE31057
      Other_name: tag-79 CGC_data_submission
        CELE_R148.6 Accession_evidence: NDB BX284603
      Public_name: heh-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: heh
    Allele (19)
    Strain: WBStrain00003220
      WBStrain00022846
      WBStrain00035732
    RNASeq_FPKM (74)
    GO_annotation: 00029566
      00029567
      00029568
      00029569
      00114094
      00114095
    Ortholog: WBGene00066383 Caenorhabditis remanei From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00039321 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00154711 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00133089 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00230507 Brugia malayi From_analysis: WormBase-Compara
      CSP26.g7430 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g22300 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g16300 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g8732 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g5770 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g7149 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g29228 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g4115 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g23128 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00432.g10785 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_02367.g17114 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-heh-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g18932 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_05152.g34480 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_15160 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_011258 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g03459 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g13007 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g23854 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_30321500 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIII_pilon.g7217 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00247808 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00265468 Strongyloides ratti From_analysis: WormBase-Compara
      FB:FBgn0031381 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
      FB:FBgn0037782 Drosophila melanogaster From_analysis: Hieranoid
            OrthoFinder
            Panther
      FB:FBgn0037783 Drosophila melanogaster From_analysis: Hieranoid
            OrthoFinder
            Panther
      FB:FBgn0038198 Drosophila melanogaster From_analysis: Hieranoid
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-021206-13 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-080723-11 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            Panther
      HGNC:14537 Homo sapiens From_analysis: Hieranoid
            OrthoFinder
            Panther
      MGI:1915213 Mus musculus From_analysis: Hieranoid
            OrthoFinder
            Panther
      RGD:628756 Rattus norvegicus From_analysis: Hieranoid
            OrthoFinder
            Panther
            PhylomeDB
    Structured_description: Concise_description: tag-79/R148.6 is orthologous to human NPC2 (OMIM:601015, mutated in Niemann-Pick disease type C2) Curator_confirmed: WBPerson1823
            WBPerson567
          Date_last_updated: 09 Aug 2004 00:00:00
      Automated_description: Predicted to enable sterol binding activity. Predicted to be involved in sterol transport. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C2. Is an ortholog of human NPC2 (NPC intracellular cholesterol transporter 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:14504 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14537)
      DOID:0070114 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14537)
  Molecular_info: Corresponding_CDS: R148.6
    Corresponding_transcript: R148.6.1
    Associated_feature: WBsf1014525
      WBsf226325
  Experimental_info: RNAi_result: WBRNAi00033286 Inferred_automatically: RNAi_primary
      WBRNAi00051970 Inferred_automatically: RNAi_primary
      WBRNAi00017868 Inferred_automatically: RNAi_primary
      WBRNAi00006770 Inferred_automatically: RNAi_primary
      WBRNAi00092949 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr6544
      Expr1013014
      Expr1032628
      Expr1155614
      Expr2012394
      Expr2030630
    Drives_construct: WBCnstr00003695
    Microarray_results (17)
    Expression_cluster (175)
    Interaction: WBInteraction000307264
      WBInteraction000347801
      WBInteraction000427415
      WBInteraction000548599
      WBInteraction000550293
  Map_info (4)
  Reference: WBPaper00024084
    WBPaper00038491
    WBPaper00042257
    WBPaper00053559
    WBPaper00055090
  Remark: Gene name created from parsing 'genotype' field from CGC strain information CGC_data_submission
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene