WormBase Tree Display for Gene: WBGene00001749

WBGene00001749 Evidence: Person_evidence: WBPerson1846
  SMap: S_parent: Sequence: R107
  Identity: Version: 1
    Name: CGC_name: gst-1
      Sequence_name: R107.7
      Molecular_name (3)
      Other_name: CE00302 Paper_evidence: WBPaper00036144
        CELE_R107.7 Accession_evidence: NDB BX284603
      Public_name: gst-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:25 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gst
    Allele (13)
    Legacy_information: [C.elegansII] NMK. Encodes predicted glutathione-S-transferase P subunit. Transpliced to SL2. [Weston et al. 1989]
    RNASeq_FPKM (74)
    GO_annotation (18)
    Contained_in_operon: CEOP3572
    Ortholog: WBGene00055267 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
      WBGene00029034 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
      WBGene00141065 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
      WBGene00137596 Caenorhabditis japonica From_analysis: OMA
            TreeFam
            Inparanoid_8
      WBGene00097568 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00225675 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g3765 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g6154 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP31.g4397 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP38.g17509 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      Cang_2012_03_13_00773.g14041 Caenorhabditis angaria From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g11296 Oscheius tipulae From_analysis: WormBase-Compara
      chrIII_pilon.g8536 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00239449 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00285430 Trichuris muris From_analysis: WormBase-Compara
      WBGene00292472 Trichuris muris From_analysis: WormBase-Compara
      WBGene00296877 Trichuris muris From_analysis: WormBase-Compara
      WBGene00296972 Trichuris muris From_analysis: WormBase-Compara
      WBGene00297266 Trichuris muris From_analysis: WormBase-Compara
      WBGene00298146 Trichuris muris From_analysis: WormBase-Compara
      WBGene00301640 Trichuris muris From_analysis: WormBase-Compara
      ZFIN:ZDB-GENE-020806-4 Danio rerio From_analysis: Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050601-1 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:4632 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            SonicParanoid
      HGNC:4634 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            SonicParanoid
      HGNC:4637 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            SonicParanoid
      HGNC:4638 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:95864 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:95865 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2385078 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:2758 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog (45)
    Structured_description: Concise_description: gst-1 encodes a putative glutathione S-transferase of the pi class;GST-1 is required for sperm to normally migrate towards a PUFA-basedsignal exuded by oocytes; gst-1(RNAi) hermaphrodites are infertile,both through aberrant loss of their own sperm and through failure ofmales to effectively inseminate them. Paper_evidence: WBPaper00028527
          Curator_confirmed: WBPerson48
            WBPerson567
          Date_last_updated: 12 Mar 2007 00:00:00
      Automated_description: Enables glutathione transferase activity. Involved in cellular detoxification; defense response to other organism; and regulation of cellular response to manganese ion. Predicted to be located in cytosol. Expressed in DA neuron. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autoimmune disease (multiple); carcinoma (multiple); and hematologic cancer (multiple). Is an ortholog of human GSTP1 (glutathione S-transferase pi 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (137)
  Molecular_info: Corresponding_CDS: R107.7
    Corresponding_transcript: R107.7.1
    Other_sequence (57)
    Associated_feature: WBsf645457
      WBsf645458
      WBsf645459
      WBsf981541
      WBsf993558
      WBsf225512
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr11048
      Expr1018206
      Expr1031042
      Expr1155346
      Expr2012303
      Expr2030539
    Drives_construct: WBCnstr00019132
      WBCnstr00036720
    Construct_product: WBCnstr00036720
    Antibody: WBAntibody00002442
    Microarray_results (22)
    Expression_cluster (205)
    Interaction (46)
  Map_info: Map: III Position: 0.129472 Error: 0.002939
    Positive: Positive_clone: R107 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (23)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene