[C.elegansII] pk19, pk2, pk23, pk24, pk16. Tc1 insertion, also excision derivatives: no obvious phenotype, some reduction in dauer formation, stronger with gpa-3(O). Cloned: gpa-2:lacZ expressed in phasmid neurons, some nerve ring neurons, PVT, sphincter. [Lochrie et al. 1991; PS; NL]
gpa-2 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that is involved in dauer formation and chemotaxis to water-soluble odorants; it is expressed in the phasmid neurons PHA and PHB, three pharyngeal neurons, one interneuron, three pairs of head neurons, and the anal sphincter muscle.
Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including defense response to Gram-negative bacterium; olfactory learning; and positive regulation of gene expression. Located in axon; neuronal cell body; and non-motile cilium. Expressed in anal sphincter muscle; ganglia; and pharyngeal cell.
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.