WormBase Tree Display for Gene: WBGene00001425

WBGene00001425 Evidence: Person_evidence: WBPerson117
  SMap: S_parent: Sequence: F13B9
  Identity: Version: 1
    Name: CGC_name: fis-2 Person_evidence: WBPerson117
      Sequence_name: F13B9.8
      Molecular_name: F13B9.8
        F13B9.8.1
        CE37102
      Other_name: CELE_F13B9.8 Accession_evidence: NDB BX284606
      Public_name: fis-2
    DB_info: Database: AceView gene XI900
        WormQTL gene WBGene00001425
        WormFlux gene WBGene00001425
        NDB locus_tag CELE_F13B9.8
        Panther gene CAEEL|WormBase=WBGene00001425|UniProtKB=Q6AHP8
          family PTHR13247
        NCBI gene 184409
        RefSeq protein NM_001029389.7
        SwissProt UniProtAcc Q6AHP8
        UniProt_GCRP UniProtAcc Q6AHP8
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: fis
    Allele (32)
    Strain (3)
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog: WBGene00058807 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00041223 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00150750 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00138590 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00228799 Brugia malayi From_analysis: WormBase-Compara
      CSP26.g18496 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g20835 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g23075 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g11995 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g3914 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g9033 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g9082 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g2663 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00383.g10073 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_X.g25558 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g10182 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00093.g4068 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_01982 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_025344 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g01122 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g2051 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0160500 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g19548 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00238855 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00283159 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00258618 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00286346 Trichuris muris From_analysis: WormBase-Compara
      WBGene00295050 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000001327 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      FB:FBgn0039969 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      ZFIN:ZDB-GENE-050506-92 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
      HGNC:21689 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      MGI:1913687 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      RGD:1306668 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
    Paralog: WBGene00001424 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: fis-2 encodes a protein similar to the yeast and human Fis1 proteins involved in mitochondrial fission; fis-2 functions downstream of, or in parallel to, the ced-3 caspase during apoptosis and does not seem to be required for mitochondrial fission but it is possible that it may function redundantly along with fis-1 and other genes; the fis-2 protein localizes to mitochondria. Paper_evidence: WBPaper00032123
          Curator_confirmed: WBPerson324
          Date_last_updated: 22 Oct 2010 00:00:00
      Automated_description: Involved in apoptotic process. Acts upstream of or within IRE1-mediated unfolded protein response. Located in mitochondrion. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is an ortholog of human FIS1 (fission, mitochondrial 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10652 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:21689)
  Molecular_info: Corresponding_CDS: F13B9.8
    Corresponding_CDS_history: F13B9.8:wp128
      F13B9.8a:wp271
    Corresponding_transcript: F13B9.8.1
    Other_sequence: CJC04355_1
      CBC11363_1
    Associated_feature: WBsf670828
      WBsf1006101
      WBsf1006102
      WBsf237667
  Experimental_info: RNAi_result: WBRNAi00030875 Inferred_automatically: RNAi_primary
      WBRNAi00044489 Inferred_automatically: RNAi_primary
      WBRNAi00114732 Inferred_automatically: RNAi_primary
      WBRNAi00114731 Inferred_automatically: RNAi_primary
      WBRNAi00013201 Inferred_automatically: RNAi_primary
      WBRNAi00114730 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1016157
      Expr1030850
      Expr1148438
      Expr2011793
      Expr2030031
    Drives_construct: WBCnstr00036959
    Construct_product: WBCnstr00009308
      WBCnstr00009309
      WBCnstr00036959
    Microarray_results (23)
    Expression_cluster (147)
    Interaction: WBInteraction000135884
      WBInteraction000232353
      WBInteraction000285065
      WBInteraction000323665
      WBInteraction000391317
      WBInteraction000416344
      WBInteraction000432886
      WBInteraction000463041
  Map_info: Map: X Position: -0.194898 Error: 0.00328
    Positive: Positive_clone: F13B9 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5153
        4200
    Pseudo_map_position
  Reference: WBPaper00032123
    WBPaper00038491
    WBPaper00044205
    WBPaper00045775
    WBPaper00055090
    WBPaper00055144
    WBPaper00059545
    WBPaper00059627
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene